Reserpine‐induced model of stress suppresses mucosal immunity

Abstract

Summary Stress contributes significantly to the development of many diseases. In clinical studies, a strong correlation between depression and immune dysfunction has been shown. Our previous studies indicated that sympathetic innervation can regulate intestinal mucosal immunity through sympathetic synapses, but the mechanism in stress/ depression-induced intestinal immune deficiency was unclear. Using a mouse model in which behavioural stress/ depression is chemically induced by reserpine, it is found that there is a substantial deficiency of intestinal local humoral and particularly specific antibody response to the antigen stimulation in reserpine-treated group. No significant difference of CD4 1 , CD8 1 or Mac1 1 cells between reserpine-treated and control groups was detected in the intestine. This deficiency is closely correlated with stress/depression. A possible correlation between stress, cytokine secretion and humoral immunity in vivo is postulated.

Evaluation of Antidepressant like Effects of Ethanolic Hypericum hookerianum and its Glycosidic Flavonoid Enriched Extract in Reserpine Induced Swiss Albino Mice

“…Reserpine is a sympathetic drug that leads to hypothermia (decreases in body temperature) which depletes catecholamine in peripheral nervous tissues and in the brain (Bao et al, 2006). Reserpine can permanently inhibit the vesicular uptake of monoamines, including nor-adrenaline, dopamine and 5-hydroxyl tryptamine which depletes monoamines in the brain and leads to depression-like syndrome in animals (Yu et al, 2011).…”

New insights into the neurobiological mechanisms of major depressive disorders

“…Some of its characteristics include psychomotor slowing, as well as a significant decrease in the level of dopamine, noradrenaline, and 5-HT [44]. Using the reserpine-induced model of stress, scientists found a notable deficiency of intestinal local humoral and particularly specific antibody response to the antigen stimulation, which are correlated with clinical depression in human [73]. Another way to induce stress is the classical forced swim test, which is frequently used by scientists to evaluate the effectiveness of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at preventing depressive-like symptoms [74].…”

Antidepressant-like effects of barley (Hordeum vulgare) in a mouse model of reserpine-induced depression

“…wt) for 2 weeks induced a significant decrease in catecholamine levels in both cortex and hippocampus. [26] Moreover, reserpine, as a sympatholytic drug depletes catecholamine in peripheral nervous tissues and in the brain, [27] can irreversibly inhibit the vesicular uptake of monoamines, including noradrenaline, dopamine, and 5-hydroxytryptamine, which depletes monoamines in the brain and produces depression-like syndrome in animals. [28] In the present study, we have tried to demonstrate that barley is able to reverse the depression in mice induced by reserpine.…”