2007
DOI: 10.1007/s11538-007-9241-x
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Resetting Behavior in a Model of Bursting in Secretory Pituitary Cells: Distinguishing Plateaus from Pseudo-Plateaus

Abstract: We study a recently discovered class of models for plateau bursting, inspired by models for endocrine pituitary cells. In contrast to classical models for fold-homoclinic (square-wave) bursting, the spikes of the active phase are not supported by limit cycles of the frozen fast subsystem, but are transient oscillations generated by unstable limit cycles emanating from a subcritical Hopf bifurcation around a stable steady state. Experimental time courses are suggestive of such fold-subHopf models because the sp… Show more

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Cited by 45 publications
(52 citation statements)
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“…Note that there are other Hopf bifurcations on Z, but these have been found (numerically) to occur on the repelling branch Z r of Z, and so we will concentrate only on those Hopfs that are O(ε) close to the fold surface L. The criticality of the fast subsystem Hopf typically differentiates between plateau and pseudoplateau bursting [47,39,56,54]. In our model system, Z H has always been found (numerically) to be subcritical so that the associated bursts are of pseudo-plateau type.…”
Section: Geometric Singular Perturbation Analysismentioning
confidence: 99%
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“…Note that there are other Hopf bifurcations on Z, but these have been found (numerically) to occur on the repelling branch Z r of Z, and so we will concentrate only on those Hopfs that are O(ε) close to the fold surface L. The criticality of the fast subsystem Hopf typically differentiates between plateau and pseudoplateau bursting [47,39,56,54]. In our model system, Z H has always been found (numerically) to be subcritical so that the associated bursts are of pseudo-plateau type.…”
Section: Geometric Singular Perturbation Analysismentioning
confidence: 99%
“…Historically, the analysis of bursting in slow/fast systems was pioneered by [40], and several treatments of pseudoplateau bursting followed suit [38,39,47,56]. In this traditional 3-fast/1-slow approach, the small oscillations are born from a slow passage through a dynamic Hopf bifurcation [36,37,3] and the MMOs are hysteresis loops that alternately jump at a fold and a subcritical Hopf (fold/sub-Hopf bursts) [41,24].…”
Section: Delayed Hopf Bifurcation and Tourbillonmentioning
confidence: 99%
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“…Both mathematical models are described by a system of nonlinear Ordinary Differential Equations (ODEs). In addition, bursting dynamics has been studied in a mathematical model (Stern model) that was developed by modification of a pituitary corticotroph cell model [4]. An important issue in the analysis of mathematical models that show bursting dynamics is clarification of the dependence of the dynamic states on a system parameter such as long-lasting external stimulation.…”
Section: Introductionmentioning
confidence: 99%
“…This approach has been very successful for understanding bursting in pancreatic islets 25 and neurons. [2][3][4]21 It has also been useful in understanding various aspects of bursting in pituitary cells such as resetting properties, 26 how fast subsystem manifolds affect burst termination, 23 and how parameter changes convert the system from one burst type to the other. 24 In the alternate one-fast/two-slow analysis, one associates a variable with an intermediate time scale with the slow subsystem rather than the fast subsystem.…”
Section: Introductionmentioning
confidence: 99%