Resetting microbiota by <i>Lactobacillus reuteri</i> inhibits T reg deficiency–induced autoimmunity via adenosine A2A receptors

He, Baokun; Hoang, Thomas K.; Wang, Ting; Ferris, Michael J.; Taylor, Christopher M.; Tian, Xin; Luo, Meng; Tran, Dat Q.; Zhou, Jain; Tatevian, Nina; Luo, Fayong; Molina, Jose G.; Blackburn, Michael R.; Gomez, Thomas H.; Roos, Stefan; Rhoads, J. Marc; Liu, Yuying

doi:10.1084/jem.20160961

Cited by 156 publications

(173 citation statements)

References 87 publications

(120 reference statements)

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“…For example, as mentioned above, studies in the lab of Versalovic showed that L. reuteri strain ATCC PTA 6475 produces vitamin B 12 and histamine; the probiotic reduced tumor necrosis factor‐α production via a protein kinase A–dependent mechanism . Subsequently, in our lab, a different strain of L. reuteri DSM 17938, which does not produce vitamin B 12 or increase histamine levels, did not reduce gut inflammation in rat intestine ex vivo, but prevented NEC and markedly attenuated multiorgan inflammation in the scurfy mouse . The mechanism involved, in contrast, was the activation of an adenosine A 2A receptor.…”

Section: Myths and Mysteriesmentioning

confidence: 55%

“…In the mouse, as in the human, there is early‐onset dermatitis, progressive multiorgan inflammation, and death within the first month of life caused by a lymphoproliferative syndrome . Oral administration of L. reuteri DSM 17938 markedly prolonged survival and reduced symptoms; treatment also reduced multiorgan inflammation by inhibiting T H 1 and T H 2 cells and their associated cytokines …”

Section: Preclinical Trials and Mechanism Of Action In Inflammatory Dmentioning

confidence: 99%

“… Lactobacillus reuteri DSM 17938 treatment increases survival (A) and reduces inflammation (B) in organs of SF mice (arrows indicate lymphocyte infiltration). From He et al …”

Section: Preclinical Trials and Mechanism Of Action In Inflammatory Dmentioning

confidence: 99%

“…91 Oral administration of L. reuteri DSM 17938 markedly prolonged survival and reduced symptoms; treatment also reduced multiorgan inflammation by inhibiting T H 1 and T H 2 cells and their associated cytokines. 92 Different probiotics influence the development and survival of different types of Tregs including T H 3, Tr1, CD4 + CD25 + , CD8 + suppressor, and γ δT cells, 63 and assist the secretion of immunomodulatory cytokines including IL-10 (which can strongly suppress T H 1driving inflammation) and transforming growth factorβ (which can promote development of Tregs) by other cells. 93 These observations suggest that probiotics have a widespread role in maintaining intestinal homeostasis and the balance between tolerance and reactivity to ingested food antigens and commensal microbes.…”

Section: Probiotics Modulate Both Innate and Adaptive Immune Systemmentioning

confidence: 99%

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Probiotics in Disease Prevention and Treatment

Liu

Tran

Rhoads

2018

The Journal of Clinical Pharma

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170

115

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Few treatments for human diseases have received as much investigation in the past 20 years as probiotics. In 2017, English-language meta-analyses totaling 52 studies determined the effect of probiotics on conditions ranging from necrotizing enterocolitis and colic in infants to constipation, irritable bowel syndrome, and hepatic encephalopathy in adults. The strongest evidence in favor of probiotics lies in the prevention or treatment of 5 disorders: necrotizing enterocolitis, acute infectious diarrhea, acute respiratory tract infections, antibiotic-associated diarrhea, and infant colic. Probiotic mechanisms of action include the inhibition of bacterial adhesion; enhanced mucosal barrier function; modulation of the innate and adaptive immune systems (including induction of tolerogenic dendritic cells and regulatory T cells); secretion of bioactive metabolites; and regulation of the enteric and central nervous systems. Future research is needed to identify the optimal probiotic and dose for specific diseases, to address whether the addition of prebiotics (to form synbiotics) would enhance activity, and to determine if defined microbial communities would provide benefit exceeding that of single-species probiotics.

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Section: Myths and Mysteriesmentioning

confidence: 55%

Section: Preclinical Trials and Mechanism Of Action In Inflammatory Dmentioning

confidence: 99%

“… Lactobacillus reuteri DSM 17938 treatment increases survival (A) and reduces inflammation (B) in organs of SF mice (arrows indicate lymphocyte infiltration). From He et al …”

Section: Preclinical Trials and Mechanism Of Action In Inflammatory Dmentioning

confidence: 99%

Section: Probiotics Modulate Both Innate and Adaptive Immune Systemmentioning

confidence: 99%

See 2 more Smart Citations

Probiotics in Disease Prevention and Treatment

Liu

Tran

Rhoads

2018

The Journal of Clinical Pharma

Self Cite

170

115

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“…The microbiota also influences the immune system by producing factors that promote Treg induction [172,173].…”

Section: Gut Microbiotamentioning

confidence: 99%

Immunomodulatory effects of probiotic supplementation during pregnancy and infancy in allergy prevention studies

Forsberg¹

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A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy

et al. 2023

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Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling the tumor microenvironment and regulating key signaling pathways in cancer cells and multiple immune cells. The use of microbial metabolites in radiotherapy and chemotherapy mitigates the severe side effects from treatment and improves the efficacy of treatment. Immunotherapy combined with microbial metabolites effectively activates the immune system to kill tumors and overcomes drug resistance. Consequently, various novel strategies have been developed to modulate microbial metabolites. Manipulation of genes involved in microbial metabolism using synthetic biology approaches directly affects levels of microbial metabolites, while fecal microbial transplantation and phage strategies affect levels of microbial metabolites by altering the composition of the microbiome. However, some microbial metabolites harbor paradoxical functions depending on the context (e.g., type of cancer). Furthermore, the metabolic effects of microorganisms on certain anticancer drugs such as irinotecan and gemcitabine, render the drugs ineffective or exacerbate their adverse effects. Therefore, a personalized and comprehensive consideration of the patient's condition is required when employing microbial metabolites to treat cancer. The purpose of this review is to summarize the correlation between gut microbiota‐derived metabolites and cancer, and to provide fresh ideas for future scientific research.

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Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency–induced autoimmunity via adenosine A2A receptors

Cited by 156 publications

References 87 publications

Probiotics in Disease Prevention and Treatment

Probiotics in Disease Prevention and Treatment

Immunomodulatory effects of probiotic supplementation during pregnancy and infancy in allergy prevention studies

A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy

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