Residence-time distribution as a measure of mixing in T-junction and multilaminated/elongational flow micromixers

Adeosun, John T.; Lawal, Adeniyi

doi:10.1016/j.ces.2009.11.038

Cited by 41 publications

(24 citation statements)

References 32 publications

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“…Most available models do not sufficiently permit the modelling of asymmetric residence time distributions as expected for complex flow patterns with a significant contribution of laminar flow. A semi-empirical model for the interpretation of residence time measurements has been proposed by Ham and Platzer [20] and found application in experimental studies on micro-structured devices with slight modifications [21][22][23][24]. This semi-empirical model is entirely independent of model assumptions for convection, diffusion and dispersion characteristics, which makes it applicable for all types of (partly) asymmetric residence time distributions.…”

Section: Residence Time Modelmentioning

confidence: 98%

Bridging the gap: A nested-pipe reactor for slow reactions in continuous flow chemical synthesis

Minnich

Greiner

Reimers

et al. 2011

Chemical Engineering Journal

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Section: Residence Time Modelmentioning

confidence: 98%

Bridging the gap: A nested-pipe reactor for slow reactions in continuous flow chemical synthesis

Minnich

Greiner

Reimers

et al. 2011

Chemical Engineering Journal

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“…In the context of the static microchannel mixers designed to improve radial/transverse mixing, a CoV of zero would imply complete plug-flow mixing while a non-zero CoV implies that there is axial dispersion or mixing caused by non-uniform or laminar velocity profile and molecular diffusion. In this case, the smaller the variance or the CoV, the narrower is the RTD, the closer is the distribution to the mean residence time, and the better the mixing quality [11], [15].…”

Section: Icmit 2016mentioning

confidence: 99%

Computational Design and Experimental Validation of SAR Mixers

2016

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Abstract. In this study, two novel split and recombine (SAR) 'H-C' and 'Y-Y' micromixers along with a known SAR 'Chain' mixer are presented. The efficiency and pressure drop at Reynolds numbers (Re) up to 100 were investigated numerically as well as experimentally. Numerical and experimental values of mixing efficiency and pressure drop coincide considerably, which validate the numerical model. Results show that the mixing efficiency of the Chain mixer is good only at Re≥50 and the pressure drop is relatively high, whereas the H-C and the Y-Y mixers give a mixing efficiency higher than 90% over all the range of Reynolds numbers examined and their energy requirement is less than that of the Chain mixer. Furthermore, numerical residence time distribution (RTD) was explored, which successfully predicts the experimental results.

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“…This set-up is still not as ideal as in situ integration where spectroscopic measurements are focused directly inside the microchannel. [12][13][14] This direct approach usually comes with the drawback of excessive cost associated with device manufacture or a reduction in portability as a result of large optical set ups. The method used in this work negates both of these issues due to the low cost of the device and the ability to incorporate small, low cost optics directly within the walls of the microchannels, without the need for UV-vis transparent waveguides.…”

Section: Optimal Path Length For Spectroscopic Measurementsmentioning

confidence: 99%

“…residence time, sample distribution and mixing) via external flow-through cells, this set-up is still not as ideal as in situ integration where spectroscopic measurements are focused directly inside the microchannel. [12][13][14] Furthermore, only a single instance of embedded optical fibres being used for direct in-line reaction monitoring and optimisation via UV-vis spectroscopy has been reported. 15 This lack of further publishing likely arises as a result of the requirement to integrate UV transparent waveguides into the channels of the device.…”

Section: Introductionmentioning

confidence: 99%

Customisable 3D printed microfluidics for integrated analysis and optimisation

et al. 2016

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The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100-500 m) means that these devices were capable of handling a wide range of concentrations (9 M-38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.

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Residence-time distribution as a measure of mixing in T-junction and multilaminated/elongational flow micromixers

Cited by 41 publications

References 32 publications

Bridging the gap: A nested-pipe reactor for slow reactions in continuous flow chemical synthesis

Bridging the gap: A nested-pipe reactor for slow reactions in continuous flow chemical synthesis

Computational Design and Experimental Validation of SAR Mixers

Customisable 3D printed microfluidics for integrated analysis and optimisation

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