Residential exposure to natural background radiation at birth and risk of childhood acute leukemia in France, 1990–2009

Berlivet, J.; Hémon, Denis; Cléro, Énora; Ielsch, Géraldine; Laurier, Dominique; Clavel, Jacqueline

doi:10.1016/j.jenvrad.2021.106613

Cited by 15 publications

(13 citation statements)

References 36 publications

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“…The authors confirmed the recent results that NBR contributes to the risk of leukemia in children (101). However, studies in France do not support an association between NBR and a higher risk of childhood acute leukemia (including ALL and AML) (102,103).…”

Section: Ionizing Radiationsupporting

confidence: 78%

Risk Factors for Childhood Leukemia: Radiation and Beyond

Schmidt

Hornhardt

Erdmann

et al. 2021

Front. Public Health

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Childhood leukemia (CL) is undoubtedly caused by a multifactorial process with genetic as well as environmental factors playing a role. But in spite of several efforts in a variety of scientific fields, the causes of the disease and the interplay of possible risk factors are still poorly understood. To push forward the research on the causes of CL, the German Federal Office for Radiation Protection has been organizing recurring international workshops since 2008 every two to three years. In November 2019 the 6th International Workshop on the Causes of CL was held in Freising and brought together experts from diverse disciplines. The workshop was divided into two main parts focusing on genetic and environmental risk factors, respectively. Two additional special sessions addressed the influence of natural background radiation on the risk of CL and the progress in the development of mouse models used for experimental studies on acute lymphoblastic leukemia, the most common form of leukemia worldwide. The workshop presentations highlighted the role of infections as environmental risk factor for CL, specifically for acute lymphoblastic leukemia. Major support comes from two mouse models, the Pax5+/− and Sca1-ETV6-RUNX1 mouse model, one of the major achievements made in the last years. Mice of both predisposed models only develop leukemia when exposed to common infections. These results emphasize the impact of gene-environment-interactions on the development of CL and warrant further investigation of such interactions — especially because genetic predisposition is detected with increasing frequency in CL. This article summarizes the workshop presentations and discusses the results in the context of the international literature.

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Section: Ionizing Radiationsupporting

confidence: 78%

Risk Factors for Childhood Leukemia: Radiation and Beyond

Schmidt

Hornhardt

Erdmann

et al. 2021

Front. Public Health

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show abstract

“…21 In a French ecological study examining natural background radiation, there was no reported association between radon and childhood CNS tumor incidence (IRR:1.02; 95% CI:0.96, 1.07), and in an American Cancer Prevention Study II cohort study, no association with brain cancer mortality was reported (HR:0.98; 95% CI:0.83, 1.15). 19,35 This is similar to occupational studies on radon exposure in uranium miners that revealed mixed results, though the majority indicate no association. 28,30,31,36 Mixed results, heterogenous study designs, and varying study populations limit definitive conclusions.…”

Section: Central Nervous System Cancersupporting

confidence: 80%

“…48 Results of radon and leukemia studies are mixed, with several studies finding both positive [54][55][56][57][58] and null associations. 35,[59][60][61][62][63][64] A meta-analysis of these studies by Lu et al observed a weak but positive association between radon exposure and leukemia (OR:1.37; 95% CI:1.02, 1.82), noting the difference between casecontrol (OR:1.22; 95% CI:1.01, 1.42) and cohort (HR:0.97; 95% CI:0.81, 1.15) studies. 47 Indeed, Tong et al noticed the majority of surveyed ecological studies (11 out of 12) found a positive association, while the majority of case-control studies found weak or no association.…”

Section: Leukemiamentioning

confidence: 99%

“…Results of radon and leukemia studies are mixed, with several studies finding both positive 54-58 and null associations. 35 , 59-64 A meta-analysis of these studies by Lu et al . observed a weak but positive association between radon exposure and leukemia (OR:1.37; 95% CI:1.02, 1.82), noting the difference between casecontrol (OR:1.22; 95% CI:1.01, 1.42) and cohort (HR:0.97; 95% CI:0.81, 1.15) studies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Residential radon exposure and cancer

Reddy¹,

Conde²,

Peterson³

et al. 2022

Oncol Rev

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Radon is an established human lung carcinogen naturally released as an odorless, colorless gas from soil and rocks. It is a major environmental source of ionizing radiation and can cause oxidative damage to DNA, increasing the risk of cancer. Although the association between radon and lung cancer is well established, the association between radon and other cancers is not. Based on reported studies, there is no consistent evidence indicating an association between radon and non-lung cancers, but limited literature, heterogenous study design, and confounding variables preclude definitive conclusions. More research is needed to evaluate the association between residential radon and non-lung cancers, particularly with regard to skin cancer, CNS cancer, and stomach cancer, in which existing literature suggests potential associations with residential radon may exist. However, the literature largely demonstrates that lung cancer is the primary concern associated with residential radon exposure and that non-lung cancers are secondary concerns. These results should be considered in residential radon mitigation efforts.

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“…The maximum doses are generally very low, in no case exceeding 0.05 Gy ( Table 1 ). Among the main studies listed in Table 1 , all are of natural background gamma radiation, but some also include assessment of the risks of radon exposure ( Berlivet et al 2021 ; Berlivet et al 2020 ; Demoury et al 2017 ; Kendall et al 2013 ). All these studies, and two studies that assessed only gamma radiation ( Nikkilä et al 2016 ; Spycher et al 2015 ) are of European national populations, and are register based.…”

Section: Resultsmentioning

confidence: 99%