Residential greenness associated with decreased risk of metabolic- dysfunction-associated fatty liver disease: Evidence from a large population-based epidemiological study

Chen, Lin; Jia, Yiping; Guo, Yuming; Chen, Gongbo; Ciren, Zhuoga; Chen, Heng; Duoji, Zhuoma; Xu, Jie; Yang, Tingting; Xu, Huan; Feng, Shiyu; Jiang, Ye; Guo, Bing; Meng, Qiong; Zhao, Xing

doi:10.1016/j.ecoenv.2022.114338

Cited by 4 publications

(5 citation statements)

References 54 publications

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“…Physical activity constitutes an important lifestyle-level intervention evidenced to improve blood supply in the frontal and parietal cortex, which in turn transforms into metabolic resources in response to daily demands . It is plausible that exposure to higher levels of residential greenness promotes greater participation in recreational activities and active lifestyle, , with accrued protective association with AL via lowering dysregulation of metabolic and cardiovascular systems. , Recent studies have reported inverse association between physical activity and allostatic load and physiological dysregulation. , Furthermore, there has been considerable accumulating evidence on the role of greenness in protecting against adiposity, vascular aging, and inflammatory and liver diseases. , An activity-facilitating natural environment may also help create opportunities for restorative processes, thereby reducing oxidative stress, which has been evident to be associated with metabolic and immune alterations and clinical conditions including cardiovascular diseases and disease predisposition . An increasing contact with nature within the neighborhood may also imply greater distance to environmental stressors such as traffic noise, which has been found to be associated with elevated levels of cardiovascular and inflammatory biomarkers …”

Section: Discussionmentioning

confidence: 99%

“…31,40 Furthermore, there has been considerable accumulating evidence on the role of greenness in protecting against adiposity, 41 vascular aging, 42 and inflammatory and liver diseases. 43,44 An activity-facilitating natural environment may also help create opportunities for restorative processes, thereby reducing oxidative stress, 19 which has been evident to be associated with metabolic and immune alterations and clinical conditions including cardiovascular diseases and disease predisposition. 45 An increasing contact with nature within the neighborhood may also imply greater distance to environmental stressors such as traffic noise, which has been found to be associated with elevated levels of cardiovascular and inflammatory biomarkers.…”

Section: ■ Discussionmentioning

confidence: 99%

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Association between Residential Greenness and Allostatic Load: A Cohort Study

Lai,

Kumari,

Gallacher

et al. 2024

Environ. Sci. Technol.

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The association between residential greenness and allostatic load (AL), a marker of composite physiological burden and predictor of chronic disease, remains understudied. This study comprised 212,600 UK Biobank participants recruited over 2007 and 2010 at the baseline. Residential greenness was modeled as the normalized difference vegetation index (NDVI) from high spatial resolution (0.50 m) color infrared imagery and measured within a 0.5 km radial catchment. AL was measured as a composite index from 13 biomarkers comprising three physiological systems (metabolic, cardiovascular, and inflammatory systems) and two organ systems (liver and kidney). Multilevel mixed-effects generalized linear models with a random intercept for UK Biobank assessment centers were employed to examine the association between residential greenness and AL. Each interquartile range (IQR = 0.24) increment in NDVI greenness was associated with lower AL (beta (β) = −0.28, 95% confidence interval (CI) = −0.55, −0.01). Consistently, relative to the lowest NDVI greenness quintile, participants in the highest quintile had lower AL (β = −0.64, 95% CI = −1.02, −0.26). The proportion of the association between greenness and AL mediated by the physical activity was 3.2%. In conclusion, residential greenness was protectively associated with AL, a composite marker of wear and tear and general health.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Association between Residential Greenness and Allostatic Load: A Cohort Study

Lai,

Kumari,

Gallacher

et al. 2024

Environ. Sci. Technol.

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“…However, the mediating role of physical activity in the relationship between green space and health is inconsistent (Dzhambov et al, 2018) and may depend on factors like quality and safety (Klompmaker et al, 2018). Six studies used physical activity as a mediator, and only two mediated the association (Chen et al, 2023;de Keijzer et al, 2019).…”

Section: Potential Mechanismsmentioning

confidence: 99%

“…Air pollution, a known contributor to chronic inflammation, has been linked to the development of metabolic syndrome (Wei et al, 2016). Four studies (Chen et al, 2023;de Keijzer et al, 2019;Yang et al, 2019) found air pollution mediated the associations between green space and metabolic syndrome. One reported that lower walkability with high NO2 was associated with increased metabolic syndrome risk (Zhu et al, 2023).…”

Section: Potential Mechanismsmentioning

confidence: 99%

“…Green space exposure may influence health (de Keijzer et al, 2019) through various mechanisms, including opportunities for physical activity and social engagement (Gong et al, 2014); reduced stress (Gong et al, 2016); and mitigated exposure to environmental hazards such as air pollution (Dadvand et al, 2012;Diener and Mudu, 2021), heat (Doick et al, 2014), and noise (Markevych et al, 2017). More specifically, studies have observed a protective association between residential greenness and the risk of metabolic syndrome (Chen et al, 2023;de Keijzer et al, 2019;Gong et al, 2014;.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Green Space and Built Environment on Metabolic Syndrome: A Systematic Review with Meta-Analysis

Patwary,

Sakhvidi,

Ashraf

et al. 2023

Preprint

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Metabolic Syndrome presents a significant public health challenge associated with an increased risk of noncommunicable diseases such as cardiovascular conditions. Evidence shows that green spaces and the built environment may influence metabolic syndrome. We conducted a systematic review and meta-analysis of observational studies published through August 30, 2023, examining the association of green space and built environment with metabolic syndrome. A quality assessment of the included studies was conducted using the Office of Health Assessment and Translation (OHAT) tool. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) assessment was used to evaluate the overall quality of evidence. Our search retrieved 18 studies that met the inclusion criteria and were included in our review. Most were from China (n=5) and the U.S. (n=5), and most used a cross-sectional study design (n=8). Nine studies (50%) reported only green space exposures, seven (39%) reported only built environment exposures, and two (11%) reported both built environment and green space exposures. Studies reported diverse definitions of green space and the built environment, such as availability, accessibility, and quality, particularly around participants’ homes. The outcomes focused on metabolic syndrome; however, studies applied different definitions of metabolic syndrome. Meta-analysis results showed that an increase in normalized difference vegetation index (NDVI) within a 500-m buffer was associated with a lower risk of metabolic syndrome (odds ratio [OR]=0.90, 95%CI=0.87−0.93, I2=22.3%, n=4). A substantial number of studies detected bias for exposure classification and residual confounding. Overall, the extant literature shows a ‘limited’ strength of evidence for green space protecting against metabolic syndrome and an 'inadequate' strength of evidence for the built environment associated with metabolic syndrome. Studies with more robust study designs, better controlled confounding factors, and stronger exposure measures are needed to understand better what types of green spaces and built environment features influence metabolic syndrome.

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Residential green and blue spaces with nonalcoholic fatty liver disease incidence: Mediating effect of air pollutants

Liu,

Yang,

et al. 2023

Ecotoxicology and Environmental Safety

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Residential greenness associated with decreased risk of metabolic- dysfunction-associated fatty liver disease: Evidence from a large population-based epidemiological study

Cited by 4 publications

References 54 publications

Association between Residential Greenness and Allostatic Load: A Cohort Study

Association between Residential Greenness and Allostatic Load: A Cohort Study

Impact of Green Space and Built Environment on Metabolic Syndrome: A Systematic Review with Meta-Analysis

Residential green and blue spaces with nonalcoholic fatty liver disease incidence: Mediating effect of air pollutants

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