Residential Radon Gas Exposure and Lung Cancer: The Iowa Radon Lung Cancer Study

Field, R. William; Steck, Daniel J.; Smith, Brian J.; Brus, Christine P.; Fisher, Eileen L; Neuberger, John S.; Platz, Charles E.; Robinson, Robert A.; Woolson, R. F.; Lynch, Charles F.

doi:10.1093/oxfordjournals.aje.a010153

Cited by 261 publications

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“…No differences were noted between the participating and the 224 non-participating controls who returned the questionnaire for the categories ever-worked, current worker, ever smoked, current smoker, and bedroom radon concentrations [5].…”

Section: Methodsmentioning

confidence: 88%

“…Controls aged 40-64 were selected from drivers' license files of the state of Iowa, while female controls aged 65-84 were selected from records of the Health Care Financing Administration. Controls were group matched on age to the cases [5]. Controls were verified against the ICR to insure that they did not have lung cancer.…”

Section: Methodsmentioning

confidence: 99%

“…Outdoor radon concentrations were also obtained through a statewide year-long radon monitoring survey [7]. Retrospective assessment of cumulative radon exposure was estimated by linkage between historical occupancy patterns and multiple radon measurements [5].…”

Section: Methodsmentioning

confidence: 99%

“…In the multivariate analysis tables, statistically significant odds-ratios are presented. The risk analysis for prolonged radon exposure is presented elsewhere [5].…”

Section: Methodsmentioning

confidence: 99%

“…A previous publication focused on residential radon exposure and lung cancer in Iowa women [5]. Our goal in this manuscript is to focus on the remaining risk factors in the Iowa Radon Lung Cancer Study.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for lung cancer in Iowa women: Implications for prevention

Neuberger

Mahnken

Mayo

et al. 2006

Cancer Detection and Prevention

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Background-Multiple risk factors possibly associated with lung cancer were examined as part of a large-scale residential radon case-control study conducted in Iowa between 1994 and 1997. We were particularly interested in stratifying risk factors by smoking status. Relatively little risk factor information is available for Midwestern rural women.Methods-Four hundred thirteen female lung cancer cases and 614 controls aged 40-84, who were residents of their current home for at least 20 years, were included. Risk factors examined included cigarette smoking, passive smoking, occupation, chemical exposure, previous lung disease, family history of cancer, and urban residence. Multiple logistic regression analysis was conducted after adjusting for age, education, and cumulative radon exposure.Results-As expected, active cigarette smoking was the major risk factor for lung cancer. While cessation of smoking was significantly associated with a reduced risk for lung cancer, the risk remained significantly elevated for 25 years. Among all cases, asbestos exposure was a significant risk. Among ex-smokers, pack-year history predominated as the major risk. Among never smokers, a family history of kidney or bladder cancer were significant risk factors (OR= 7.34, 95% CI = 1.91 -28.18; and 5.02, 95% CI = 1.64-15.39, respectively), as was a history of previous lung disease (OR=2.28, 95% CI=1.24-4.18) and asbestos exposure. No statistically significant increase in lung cancer risk was found for occupation or urban residence.Conclusions-Smoking prevention activities are urgently needed in rural areas of the United States. Relatives of individuals with smoking-related cancers are potentially at increased risk. Genetic risk factors should be more fully investigated in never smokers.

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Section: Methodsmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…In the multivariate analysis tables, statistically significant odds-ratios are presented. The risk analysis for prolonged radon exposure is presented elsewhere [5].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk factors for lung cancer in Iowa women: Implications for prevention

Neuberger

Mahnken

Mayo

et al. 2006

Cancer Detection and Prevention

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Radiation Epidemiology

Ron¹,

Lubin²

2005

Encyclopedia of Biostatistics

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Radiation epidemiology is a specialized field of epidemiology that seeks to characterize and quantify the health risks associated with exposure to ionizing and nonionizing radiation. One of the principal aims of radiation epidemiology is to provide the human data needed to recommend or set protection standards for workers and the general public. The data also are used to estimate levels of risk from diagnostic radiation procedures, to indicate how radiotherapy protocols can be improved to reduce acute and long‐term side effects, to better understand individual susceptibility, and to learn more about disease mechanisms.

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Radon

Ginevan¹

2001

Encyclopedia of Environmetrics

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Residential Radon Gas Exposure and Lung Cancer: The Iowa Radon Lung Cancer Study

Cited by 261 publications

References 0 publications

Risk factors for lung cancer in Iowa women: Implications for prevention

Risk factors for lung cancer in Iowa women: Implications for prevention

Radiation Epidemiology

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