Residential traffic noise exposure and vestibular schwannoma – a Danish case–control study

Roswall, Nina; Stangerup, Sven‐Eric; Cayé‐Thomasen, Per; Schüz, Joachim; Johansen, Christoffer; Jensen, Steen Solvang; Raaschou-Nielsen, Ole; Sørensen, Mette

doi:10.1080/0284186x.2017.1337925

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…For example, this bias is commonly observed in the vestibular schwannoma literature, in which persons will report significant exposures related to hearing (eg, occupational noise exposure) after learning that they have developed a tumor on their hearing nerve; however, prior objective, population-based studies that do not rely on surveys demonstrate no such association. [18][19][20] Considering these methodological limitations of prior research, we believe the data from the current study do not support the assertion that pregnancy increases the risk of developing otosclerosis nor does it contribute to worsening hearing loss.…”

Section: Discussioncontrasting

confidence: 87%

Pregnancy, Estrogen Exposure, and the Development of Otosclerosis: A Case‐Control Study of 1196 Women

Macielak¹,

Marinelli²,

Totten

et al. 2020

Otolaryngol.--head neck surg.

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Objective This study sought to determine whether a history of pregnancy or bilateral oophorectomy is associated with subsequent otosclerosis development or disease severity. Study Design Population-based case-control study. Setting Olmsted County, Minnesota. Methods Women diagnosed with otosclerosis were matched to 3 women without otosclerosis based on age and historical depth of medical records. Associations of prior delivery and bilateral oophorectomy with subsequent development of otosclerosis and with pure-tone average (PTA) at the time of otosclerosis diagnosis were evaluated. Results We studied 1196 women: 299 cases of otosclerosis and 897 matched controls. The odds ratio for the association of ≥1 delivery with otosclerosis was 1.16 (95% confidence interval [CI] 0.85-1.60; P = .35). Odds ratios for the associations of 1, 2, 3, or ≥4 deliveries with otosclerosis were 1.22 (0.83-1.80), 1.09 (0.71-1.68), 1.28 (0.77-2.12), and 1.00 (0.54-1.84), respectively. The odds ratio for the association of prior bilateral oophorectomy with otosclerosis was 1.12 (0.58-2.18; P = .73). In cases with otosclerosis, PTA at diagnosis was not significantly higher for women with ≥1 delivery as compared with those without (median 45 dB hearing loss [HL] [interquartile range {IQR} 36-55] vs 43 [IQR 34-53]; P = 0.18) but was significantly higher for women with bilateral oophorectomy compared with those without (median 54 dB HL [IQR 44-61] vs 44 [IQR 34-53]; P = .03). Conclusion These data do not support a relationship between endogenous estrogen exposure and development of otosclerosis. Women with otosclerosis who had a history of pregnancy did not have significantly worse hearing at the time of diagnosis, suggesting that pregnancy is not associated with disease severity.

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Section: Discussioncontrasting

confidence: 87%

Pregnancy, Estrogen Exposure, and the Development of Otosclerosis: A Case‐Control Study of 1196 Women

Macielak¹,

Marinelli²,

Totten

et al. 2020

Otolaryngol.--head neck surg.

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“…Although several survey-based studies have reported an association between noise exposure and the development of sporadic VS 19,20 or between cell phone use and sporadic VS, 21 several robust population-based case-control studies have refuted these claims. [22][23][24] The apparent discrepancy is most likely accounted for by the susceptibility of the aforementioned survey-based studies to recall bias, where patients who have been diagnosed with a tumor on their hearing nerve are Several incidence rates were reported in this study; however, for reasons exhaustively described in the original study, the rate of 3.3 per 100,000 personyears likely represents the most accurate estimate reported based on completeness of data. 10 reasonably more likely to note exposures related to hearing.…”

Section: Discussionmentioning

confidence: 73%

“…Although several survey-based studies have reported an association between noise exposure and the development of sporadic VS 19,20 or between cell phone use and sporadic VS, 21 several robust population-based case-control studies have refuted these claims. 22-24 The apparent discrepancy is most likely accounted for by the susceptibility of the aforementioned survey-based studies to recall bias, where patients who have been diagnosed with a tumor on their hearing nerve are reasonably more likely to note exposures related to hearing. Similarly, patients with significant cell phone use may be more sensitive to asymmetrical hearing loss and consequently undergo workup.…”

Section: Discussionmentioning

confidence: 99%

Global Incidence of Sporadic Vestibular Schwannoma: A Systematic Review

Marinelli¹,

Beeler

Carlson³

et al. 2021

Otolaryngol.--head neck surg.

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Objective Ubiquitous throughout the literature and during patient counseling, vestibular schwannoma is often quoted to affect about 1 per 100,000 people. Yet, reports from distinct international populations suggest that the incidence is likely much higher. The objective of the current work was to systematically characterize the global incidence of sporadic vestibular schwannoma. Data Sources Scopus, Embase, and PubMed. Review Methods Population-based studies reporting incidence rates of sporadic vestibular schwannoma between January 2010 and August 2020 were searched with language restrictions requiring reports to be published in Chinese, English, German, Italian, or Spanish. The protocol was registered with PROSPERO (CRD42021228208) prior to commencement of data collection. PRISMA guidelines for transparent reporting of systematic reviews were followed. Results Among 424 citations, 6 publications covering 4 distinct populations from Denmark, the Netherlands, Taiwan, and the United States met inclusion criteria. Most recent incidence rates of among all ages ranged between 3.0 and 5.2 per 100,000 person-years. Highest incidence rates were reported among patients aged ≥70 years, peaking at 20.6 per 100,000 person-years. One study from the United States reported the incidence of asymptomatic, incidentally diagnosed tumors at a rate of 1.3 per 100,000 person-years from 2012 to 2016. Conclusions Recent international incidence rates of sporadic vestibular schwannoma exceed the commonly quoted “1 per 100,000” figure by up to 5-fold among all ages and by up to 20-fold among age groups at highest risk. Based on modern incidence rates, the lifetime prevalence of developing sporadic vestibular schwannoma likely exceeds 1 per 500 persons.

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“…None of the studies are prospective, randomized or blinded but mostly case–control studies. Of importance, no association has been found between occupation, traffic/loud noise nor the use of mobile phones and tumor occurrence 34–37. Lastly, exposure to radiation is known to cause neoplasms including intracranial 38–41…”

Section: Discussionmentioning

confidence: 99%

<p>Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort</p>

Reznitsky

Petersen

West

et al. 2019

CLEP

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119

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ObjectiveReports on the epidemiology of vestibular schwannoma (VS) indicate an increase in diagnosed cases, often based on selected materials over a limited period of time. This report presents prospective 40-year epidemiological data from an unselected national cohort of all patients diagnosed with a VS in Denmark since 1976.Study-designData on gender, age, tumor localization and size registered during the period 1976–2015 were retrieved.Results3637 new cases of VS were diagnosed during the 40-year period. The annual number of diagnosed VS increased from 14 in 1976 to 193 in 2015. Mean extrameatal tumor size decreased from 26mm in 1976 to 13.4mm in 2015. Large and giant tumors were more frequent during the first decades, whereas predominantly smaller tumors were diagnosed during the recent years. Median age at diagnosis increased gradually from 49.2 years in 1976 to 60 years in 2015.ConclusionOver the past 40 years, the incidence rate of vestibular schwannomas has increased steadily from 3 VS/million/year to 34 VS/million/year, primarily due to easier access to improved diagnostics and the finding of more tumors in older people. Concurrently, the diagnostic tumor size has decreased from 26mm to 7mm, and the age at diagnosis has increased from 49 to 60 years.

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Residential traffic noise exposure and vestibular schwannoma – a Danish case–control study

Abstract: The present study does not suggest an association between residential traffic noise and VS.

Cited by 9 publications

References 25 publications

Pregnancy, Estrogen Exposure, and the Development of Otosclerosis: A Case‐Control Study of 1196 Women

Pregnancy, Estrogen Exposure, and the Development of Otosclerosis: A Case‐Control Study of 1196 Women

Global Incidence of Sporadic Vestibular Schwannoma: A Systematic Review

<p>Epidemiology Of Vestibular Schwannomas – Prospective 40-Year Data From An Unselected National Cohort</p>

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