Residents had an Increasing Risk of Norovirus Gastroenteritis Infection Than Health Care Workers During an Outbreak in a Nursing Home

Yang, Li-Chu; Chiang, Ping-Cherng; Huang, Tsui-Chin; Chi, Su-Fen; Chiu, Yueh-Pi; Lin, Chia‐Pin; Chou, Yen-Fang; Hsu, Sheng-Chieh; Zhang, Xiu-Se; Huang, Chi‐Che; Kao, Chen-Yi; Lin, Cheng‐Han

doi:10.1016/j.jamda.2009.12.089

Cited by 12 publications

(6 citation statements)

References 14 publications

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“…Previous studies have indicated that the NV positive rate differs significantly between AGE (16.1%) and asymptomatic (5.2%) [21]. The NV positive rate (11%) among AGE patients in this study was similar to those in Taiwan (10.5%) [22] and Australia (11.4%) [23]. In this study, the NV positive detection rate although was so low, but its prevalence rate was in accordance with other reports about the recent Taiwan situation (2007 prevalence of 8.2%, 2010 prevalence of 14.6%) [10,12].…”

Section: Discussionsupporting

confidence: 73%

Epidemiological and molecular analysis of human norovirus infections in Taiwan during 2011 and 2012

Tang

Chen

et al. 2013

BMC Infect Dis

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BackgroundThe human norovirus (NV) circulates worldwide and is a major cause of epidemics, which have increased in Taiwan since 2002. NV in acute gastroenteritis (AGE) and non-acute gastroenteritis (asymptomatic) patients, including children and adults, have not been previously examined in Taiwan; therefore, we examined the epidemiology and phylogeny of NV in AGE and asymptomatic patients of all ages.Methods253 stool samples were collected from August 2011 to July 2012 (including 155 AGE and 98 asymptomatic samples in Taiwan) and analyzed using reverse transcription-polymerase chain reaction (RT-PCR) for NV. Primers targeting the RNA-polymerase gene were used for RT-PCR to allow DNA sequencing of Taiwan NV strains and phylogenetic analyses.ResultsNV was detected in 24 (9.5%) of 253 stool specimens using RT-PCR. NV was isolated from all age groups (1 to 86 y) and those NV-positive samples were major identified from inpatients (79.2%, 19/24). Statistical analysis showed that the NV infectious rate of AGE patients was statistically significant (P < 0.05) for age, season and water type, respectively. Phylogenetic analyses of the RdRp region sequence showed that 24 NV isolates belonged to Genogroup II Genotype 4 (GII.4). They were closely related to the epidemic strain in Taiwan in 2006, the GII.4-2006b pandemic strain in 2006, and the GII.4-New Orleans strain in 2010.ConclusionThis study is the first to examine NV in sporadic AGE and asymptomatic patients in Taiwan. Furthermore, epidemic strains of isolated GII.4 were predominant in Taiwan during 2011 and 2012.

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Section: Discussionsupporting

confidence: 73%

Epidemiological and molecular analysis of human norovirus infections in Taiwan during 2011 and 2012

Tang

Chen

et al. 2013

BMC Infect Dis

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“…Owing to their ease of production, the 24-mer P particles have been utilised as tools for extensive mutagenesis studies (Bu et al, 2008;Chen et al, 2011;Tan et al, 2009Tan et al, , 2008b and phenotypic characterisation of noroviruses (Yang et al, 2010). Since P particles are composed of the same surface antigens as the norovirus, they have the potential to become a promising vaccine against noroviruses (Tan et al, 2008a(Tan et al, , 2011b.…”

Section: Introductionmentioning

confidence: 99%

Structure, stability and dynamics of norovirus P domain derived protein complexes studied by native mass spectrometry

Bereszczak

Barbu

Tan

et al. 2012

Journal of Structural Biology

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“…Although viral shedding may begin 24 hours before symptom onset, it is most common during the symptomatic phase of illness, lasting for approximately 72 hours on average. In some immunocompetent persons, viral shedding may persist for 22 days or more after recovery and even up to 2 years in transplant populations …”

Section: Epidemiology Pathogenesis and Transmissionmentioning

confidence: 99%

Norovirus Infections in Long‐Term Care Facilities

Rajagopalan

Yoshikawa

2016

J American Geriatrics Society

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Noroviruses have emerged as one of the leading causes of viral gastroenteritis worldwide, affecting community-dwelling and institutionalized older adults. Recent global epidemics present a growing challenge to the healthcare system and to long-term care facilities. Noroviruses spread readily and rapidly through multiple routes (e.g., person-to-person contact, contact with contaminated surfaces, airborne dissemination of vomitus) and thus are able to sustain an epidemic efficiently and successfully. Although norovirus gastroenteritis is a short self-limited illness in healthy immunocompetent individuals, it can result in significant morbidity and mortality in vulnerable compromised persons such as frail elderly persons and older residents of nursing homes. Diagnosis is made by clinical assessment and confirmed primarily by stool evaluation using polymerase chain reaction. Treatment is confined to supportive measures. Public health prevention and control strategies provide guidance regarding surveillance and the necessary steps to curb the clinical effect and spread of norovirus infections in various settings, including long-term care.

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Residents had an Increasing Risk of Norovirus Gastroenteritis Infection Than Health Care Workers During an Outbreak in a Nursing Home

Cited by 12 publications

References 14 publications

Epidemiological and molecular analysis of human norovirus infections in Taiwan during 2011 and 2012

Epidemiological and molecular analysis of human norovirus infections in Taiwan during 2011 and 2012

Structure, stability and dynamics of norovirus P domain derived protein complexes studied by native mass spectrometry

Norovirus Infections in Long‐Term Care Facilities

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