Residual anthelmintic activity of abamectin in artificially infected calves

Yazwinski, T. A.; Tucker, Chris; Featherston, H

doi:10.1136/vr.134.8.195

Cited by 9 publications

(6 citation statements)

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“…Similar to previous findings regarding nematocidal effectiveness of ivermectin and doramectin (Yazwinski andothers 1986, 1994b, respectively), N helvetianus infections encountered in the current study proved least effectively removed by treatment. Only fourth stage larvae populations in doramectin-treated calves were significantly reduced from the control (P<0-05).…”

Section: Obsupporting

confidence: 90%

Abstract

1997

Veterinary Record

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TABLE 1: Therapeutic efficacies of doramectin and ivermectin given subcutaneously at 200 sg/kg against gastrointestinal nematodes of cattleworm counts and percentage efficacies* Control calves Doramectin-treated calves Ivermectin-treated calves Geometric Geometric % Geometric % Nematode Stage mean Range mean Range Efficacy mean Range Efficacy Haemonchus placei Adult 240.0a 0-913 o0ob o-0 100o0 o0ob o-0 100-0 Trichostrongylus axei Adult 661 .3a 70-15,630

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Section: Obsupporting

confidence: 90%

Abstract

1997

Veterinary Record

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“…Actual efficacies of the anthelmintics used during the rearing of the study birds cannot be elucidated from these results, as many factors other than true anthelmintic efficacy undoubtedly contributed to the populations of the helminths quantified in the survey (e.g., bird challenge posttreatment, efficiency of drug deliveries, dosage rates). In early studies, however, piperazine was shown to confer little efficacy regardless of dose rate [13], and benzimidazoles (fenbendazole and albendazole) have been shown to elicit good levels of efficacy, which most recently appear to be on the decrease [14]. that helminth infections of broiler breeders are extremely common and of high magnitude, existing at levels of infection that would translate into production and economic losses in the field.…”

Section: Resultsmentioning

confidence: 99%

A survey on the incidence and magnitude of intestinal helminthiasis in broiler breeders originating from the southeastern United States

Yazwinski

Tucker

Wray

et al. 2013

Journal of Applied Poultry Research

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Primary Audience: Breeder Flock Managers, Live Production Managers, Veterinarians, Nutritionists SUMMARYA survey was conducted to determine the incidence and magnitudes of parasitic helminth populations in broiler breeders. To that end, intact intestinal tracts were submitted by personnel from 10 poultry companies located in the southeastern United States. A total of 281 intestines were submitted, with 5 to 6 intestines being submitted from each of 47 breeder barns representing the 10 poultry companies. The birds selected for sacrifice were obtained at random from each barn, and ranged in age from approximately 30 to 49 wk at posting. Intestines were extracted on site, placed individually in plastic bags, chilled, and mailed overnight to the University of Arkansas for parasite collection, identification, and quantification. All intestines were identified with company, farm, bird age, and grower ranking. The majority of intestines were submitted with information relative to anthelmintic treatments given previously to the birds in the pullet house as well as specifics concerning bedding (number of flocks on current bedding). Of the 281 intestines submitted in the survey, only 3 were found to be void of helminth parasites, resulting in an overall infection incidence of 98.9%. Helminths isolated and identified from the intestinal tracts (and overall incidences) were Heterakis gallinarum (96%), Capillaria obsignata (75%), Ascaridia galli (63%), and Raillietina cesticillus (14%). Helminth counts for individual birds ranged from zero to a maximum of 3,240, 1,280, 940, and 445 for H. gallinarum, C. obsignata, A. galli, and R. cesticillus, respectively. Helminth levels varied significantly by company, but not significantly by grower ranking, although a direct correlation was evident between each parasite population and grower ranking (lower producer rankings were associated with higher helminth burdens). No correlation was detected between the helminth levels as seen in the surveyed birds and prior anthelmintic usage when the birds were in pullet production-an illustration of the refractory or compensatory nature of helminths and the inability of current treatments to control helminthiasis in breeders.

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“…Ivermectin (Ivomec; Merck, Sharp & Dohme) was first marketed in 1981 as a broad‐spectrum, injectable endectocide for use in cattle (Egerton and others 1980). Since then, it has been extensively used in cattle around the world in the injectable formulation, as a topical solution (Yazwinski and others 1986) and, most recently, as delivered from a reticulum‐retained bolus designed for sustained release over a 135‐day period (Yazwinski and others 1995). Doramectin (Dectomax; Pfizer) differs from ivermectin in that doramectin has a double bond from carbon 22 to 23 and a non‐polar, cyclohexyl group at carbon 25 (Shoop 1993).…”

Section: Control Calves Doramectin‐treated Calves Ivermectin‐treated mentioning

confidence: 99%