Gujarat during the kharif and summer season of 2021-22 and 2022-23, to study the response of integrated nutrient management on Bt. cotton-groundnut cropping sequence. The experiment was laid out in a randomized block design in Bt. cotton with 5 treatments and 4 replications, while split plot design was laid out in summer groundnut with 10 treatments and 4 replications. Application of 75% RDN through inorganic fertilizer + 25% RDN through vermicompost along with Bio NPK consortium to kharif cotton increased the net return of of ₹ 111955/ha, while application of 100% RDN through inorganic fertilizer recorded maximum BCR of 5.26, followed by 2.41 in 75% RDN through inorganic fertilizer + 25% RDN through vermicompost + Bio NPK consortium (C5). In succeeding summer groundnut, residual effect of 75% RDN through inorganic fertilizer + 25% RDN through vermicompost along with Bio NPK consortium and 100% RDF recorded maximum return of of ₹ 157619 per hectare with BCR of 4.05.