Residual Effects of Cannabis Use on Effort-Based Decision-Making

Taylor, Mackenzie; Filbey, Francesca M.

doi:10.1017/s1355617721000473

Cited by 6 publications

(3 citation statements)

References 60 publications

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“…A study that used a behavioural motivation task, found that an adolescent regular cannabis use sample, switched sooner than controls from a progressive ratio reinforcement schedule based on effortful responses, in exchange for receipt of monetary reward, to a "nonwork" reinforcement schedule (Lane et al, 2005). In contrast, investigation using the EEfRT revealed that a light-using cannabis group chose high effort trials more often than controls (Taylor & Filbey, 2021), translating to increased motivation for monetary reward; this relationship was strengthened among those who report greater cannabis use (Acuff et al, 2022). However, participants under acute cannabis intoxication show significantly decreased effort exertion for reward, compared to placebo (Lawn et al, 2016), in a dose-dependent manner (Wardle et al, 2022).…”

Section: Reward Learning Motivation and The 'Amotivational Syndrome'mentioning

confidence: 99%

Reward learning capacity in a community sample of individuals who use cannabis.

Turner,

Punia,

Pizzagalli

et al. 2024

Experimental and Clinical Psychopharmacology

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Cannabis use has been linked to deficient reward processing; however, little is known about its relation to the specific construct of reward learning, in which behavior is modified through associating novel stimuli with a positive outcome. The probabilistic reward task was used to objectively evaluate reward learning in 38 individuals who use recreational cannabis and 34 control comparison participants from the community. Reward learning was evidenced by the development of a response bias, which indicates the propensity to modulate behavior as a function of prior reinforcement. Both cannabis and control groups demonstrated reward learning, with no group differences in response bias development. Among cannabis participants, trending significant relationships between greater chronicity, r(36) = −.30, p = .077, self-reported potency, r(19) = −.33, p = .052, and poorer reward learning were found. Nonsignificant relationships were found between reward learning and frequency, age of initiation, weekly quantity or Cannabis Use Disorder Identification Test-Revised (CUDIT-R) scores (all p > .05). The ability to form noncannabis reward associations is promising for the success of therapeutic interventions for problematic cannabis use; however, indications of severity of use in relation to poorer reward learning suggests a need for a better pharmacological and pharmacokinetic understanding of cannabis. Public Health SignificanceThis study suggests that individuals who use cannabis maintain the ability to form reward associations outside of the substance, while highlighting the importance of considering severity of use when evaluating this relationship.

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Section: Reward Learning Motivation and The 'Amotivational Syndrome'mentioning

confidence: 99%

Reward learning capacity in a community sample of individuals who use cannabis.

Turner,

Punia,

Pizzagalli

et al. 2024

Experimental and Clinical Psychopharmacology

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“…Previous studies using similar behavioural assessments of motivation have yielded mixed evidence for altered effort-based decision-making for reward in cannabis users, with the three most recent studies finding a positive association between cannabis use and willingness to expend effort for reward on the EEfRT (Taylor and Filbey, 2021;Acuff et al, 2022;Vele et al, 2022). Unlike the EEfRT, rewards in the PhEft are food-based and nonprobabilistic, which could explain the difference in findings.…”

Section: Behavioural Tasksmentioning

confidence: 99%

“…Lane et al (2005) found lower motivation in 14 adolescent cannabis users compared to 20 controls, whereas Lawn et al (2016) did not find a similar effect in 40 adult users and controls. More recently, and using larger samples of 86 participants and 60 participants, respectively, both Taylor and Filbey (2021) and Vele et al (2022) found that adult cannabis users selected hard trials on the EEfRT more often than adult controls. Similarly, Acuff et al (2022) found that frequency of cannabis use and symptoms of cannabis use disorder were positively associated with selecting a high-effort trial in a sample of 47 young adult cannabis users and controls.…”

Section: Introductionmentioning

confidence: 99%

Anhedonia, Apathy, Pleasure, and Effort-Based Decision-Making in Adult and Adolescent Cannabis Users and Controls

Skumlien

Mokrysz

Freeman

et al. 2022

International Journal of Neuropsychopharmacology

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Background Cannabis use may be linked with anhedonia and apathy. However, previous studies have shown mixed results and few have examined the association between cannabis use and specific reward sub-processes. Adolescents may be more vulnerable to harmful effects of cannabis than adults. This study investigated (1) the association between non-acute cannabis use and apathy, anhedonia, pleasure, and effort-based decision-making for reward, and (2) whether these relationships were moderated by age-group. Methods We used data from the ‘CannTeen’ study. Participants were 274 adult (26-29 years) and adolescent (16-17 years) cannabis users (1-7 days/week use in the past three months), and gender- and age-matched controls. Anhedonia was measured with the Snaith-Hamilton Pleasure Scale (n=274), and apathy was measured with the Apathy Evaluation Scale (n=215). Effort-based decision-making for reward was measured with the Physical Effort task (n=139), and subjective wanting and liking of rewards was measured with the novel Real Reward Pleasure task (n=137). Results Controls had higher levels of anhedonia than cannabis users (F1,258=5.35, p=.02, ηp2=.02). There were no other significant effects of User-Group and no significant User-Group*Age-Group interactions. Null findings were supported by post hoc Bayesian analyses. Conclusion Our results suggest that cannabis use at a frequency of three to four days per week is not associated with apathy, effort-based decision-making for reward, reward wanting, or reward liking in adults or adolescents. Cannabis users had lower anhedonia than controls, albeit at a small effect size. These findings are not consistent with the hypothesis that non-acute cannabis use is associated with amotivation.

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