Residual efficacy of the neonicotinoid insecticide clothianidin against pyrethroid‐resistant <i>Aedes aegypti</i>

Che-Mendoza, Azael; González-Olvera, Gabriela; Medina-Barreiro, Anuar; Arisqueta-Chablé, Carlos; Herrera-Bojórquez, Josué; Bibiano-Marín, Wilberth; Kirstein, Oscar D.; Gm, Vazquez-Prokopec; Manrique-Saide, Pablo

doi:10.1002/ps.7231

Cited by 3 publications

(1 citation statement)

References 25 publications

(50 reference statements)

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“…aegypti from the trial site showed that cone bioassays provide poor results in surfaces treated with SumiShield 50 WG compared to the insecticide's impact on free-flying mosquitoes (released in experimental houses). While delayed mortality in cones reached a maximum of 60% at 1 month post-spraying, delayed mortalities higher than 80% were maintained up to 7 months when mosquitoes were exposed in experimental houses 49 . This difference may be the product of the insecticide mode of action.…”

Section: Discussionmentioning

confidence: 94%

Preventive residual insecticide applications successfully controlled Aedes aegypti in Yucatan, Mexico

Vázquez-Prokopec

Che-Mendoza

Kirstein

et al. 2022

Sci Rep

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Insecticide-based approaches remain a key pillar for Aedes-borne virus (ABV, dengue, chikungunya, Zika) control, yet they are challenged by the limited effect of traditional outdoor insecticide campaigns responding to reported arboviral cases and by the emergence of insecticide resistance in mosquitoes. A three-arm Phase II unblinded entomological cluster randomized trial was conducted in Merida, Yucatan State, Mexico, to quantify the entomological impact of targeted indoor residual spraying (TIRS, application of residual insecticides in Ae. aegypti indoor resting sites) applied preventively 2 months before the beginning of the arbovirus transmission season. Trial arms involved the use of two insecticides with unrelated modes of action (Actellic 300CS, pirimiphos-methyl, and SumiShield 50WG, clothianidin) and a control arm where TIRS was not applied. Entomological impact was quantified by Prokopack adult collections performed indoors during 10 min per house. Regardless of the insecticide, conducting a preventive TIRS application led to significant reductions in indoor Ae. aegypti densities, which were maintained at the same levels as in the low arbovirus transmission period (Actellic 300CS reduced Ae. aegypti density up to 8 months, whereas SumiShield 50WG up to 6 months). The proportional reduction in Ae. aegypti abundance in treatment houses compared to control houses was 50–70% for Actellic 300CS and 43–63% for SumiShield 50WG. Total operational costs including insecticide ranged from US$4.2 to US$10.5 per house, depending on the insecticide cost. Conducting preventive residual insecticide applications can maintain Ae. aegypti densities at low levels year-round with important implications for preventing ABVs in the Americas and beyond.

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Section: Discussionmentioning

confidence: 94%

Preventive residual insecticide applications successfully controlled Aedes aegypti in Yucatan, Mexico

Vázquez-Prokopec

Che-Mendoza

Kirstein

et al. 2022

Sci Rep

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Nornicotine‐Typed Insecticides: The Potential Insecticides with Strong Activity Against Aedes Albopictus

Cao,

Deng,

Zhang

et al. 2024

ChemistrySelect

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Aedes albopictus, the main vector of dengue, yellow fever, chikungunya, and Zika, has caused significant public health concerns, but there are still few effective insecticides. Nicotine and nornicotine‐typed compounds are well‐known for their potential as an insecticide, which has potential activity against Ae. albopictus. Here we report the effects of nornicotine‐typed insecticide against larvae of Ae. albopictus. We developed a novel synthetic strategy for nicotine and nornicotine‐typed compounds. Novel compounds A1‐A8 and B1‐B26 were synthesized by the synthesized nornicotine. And bioassays indicated that most of these compounds exhibited good effects against larvae of Ae. albopictus, and compounds A3, B4, B20, and B26 had excellent activity against Ae. albopictus, and they were not toxic to humans according to other reports. After considering the cost, compounds B4, B20, and B26 could be potential lead compounds against Ae. albopictus and other Aedes mosquitoes.

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Wolbachia pipientis (Rickettsiales: Rickettsiaceae) mediated effects on the fitness and performance of Aedes aegypti (Diptera: Culicidae) under variable temperatures and initial larval densities

Duran-Ahumada,

Karrer,

Cheng

et al. 2024

Journal of Medical Entomology

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Wolbachia pipientis (Hertig, 1936), also referred as Wolbachia, is a bacterium present across insect taxa, certain strains of which have been demonstrated to impact the fitness and capacity to transmit viruses in mosquitoes, particularly Aedes aegypti (Linnaeus, 1762). Most studies examine these impacts in limited sets of environmental regimes. Here we seek to understand the impacts of environmentally relevant conditions such as larval density, temperature, and their interaction on wAlbB-infected A. aegypti. Using a factorial design, we measured wAlbB stability (relative density, post-emergence in females, and in progeny), the ability for wAlbB to induce cytoplasmic incompatibility, and bacterial effects on mosquito fitness (fecundity, fertility, and body mass) and performance (adult survival and time to pupation) across 2 temperature regimes (fluctuating and constant) and 2 initial larval densities (low and high). Fluctuating daily regimes of temperature (27 to 40 °C) led to decreased post-emergence wAlbB density and increased wAlbB density in eggs compared to constant temperature (27 °C). An increased fecundity was found in wAlbB-carrying females reared at fluctuating temperatures compared to uninfected wild-type females. wAlbB-carrying adult females showed significantly increased survival than wild-type females. Contrarily, wAlbB-carrying adult males exhibited a significantly lower survival than wild-type males. We found differential effects of assessed treatments (Wolbachia infection status, temperature, and larval density) across mosquito sexes and life stages. Taken together, our results indicate that realistic conditions may not impact dramatically the stability of wAlbB infection in A. aegypti. Nonetheless, understanding the ecological consequence of A. aegypti-wAlbB interaction is complex due to life history tradeoffs under conditions faced by natural populations.

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Residual efficacy of the neonicotinoid insecticide clothianidin against pyrethroid‐resistant Aedes aegypti

Cited by 3 publications

References 25 publications

Preventive residual insecticide applications successfully controlled Aedes aegypti in Yucatan, Mexico

Preventive residual insecticide applications successfully controlled Aedes aegypti in Yucatan, Mexico

Nornicotine‐Typed Insecticides: The Potential Insecticides with Strong Activity Against Aedes Albopictus

Wolbachia pipientis (Rickettsiales: Rickettsiaceae) mediated effects on the fitness and performance of Aedes aegypti (Diptera: Culicidae) under variable temperatures and initial larval densities

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