Residual foot-and-mouth disease virus antibodies 
in French cattle and sheep six years 
after the vaccination ban

Remond, Michèle; Kaiser, C.; Lebreton, Françoise; Moutou, François; Crucière, Catherine

doi:10.1051/vetres:2001112

Cited by 7 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies stated that infection-induced FMD NSP antibodies could persist for a long duration [40,41]. Another study reported that neutralising antibodies could persist for several years [42]. In our study, even though seroprevalence of the cattle aged more than three years group was higher than less than or equal to 3 years group, statistical analysis showed no signi cant difference between seroprevalence of these groups.…”

Section: Discussioncontrasting

confidence: 60%

Foot-and-mouth disease Non-Structural Protein seropositivity in cattle and pigs in Cambodia

Kong

Siengsanan-Lamont

Tum

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Foot-and-mouth disease (FMD) is a contagious transboundary animal disease that causes economic loss and obstacles to international trade. Frequent FMD outbreaks in Cambodia negatively impact farmers and smallholder incomes. This study aimed to estimate the seroprevalence of FMD Non-Structural Protein (NSP) antibodies, which are indicator antibodies raised during a natural infection rather than those which may be vaccine-derived and analyzed by enzyme‑linked immunosorbent assay (ELISA). Results: Sample collection from cattle and pigs (n=2,238) was performed at ten abattoirs in seven provinces between October 2019 and December 2020. Overall seroprevalence in cattle and pigs was 43.2% (n=839) and 0.6% (n=1,399) respectively. In cattle, the abattoir with the highest seroprevalence was in Battambang (54.5%, n=110), followed by the abattoirs in Siem Reap at 52.3% (n=109), Prey Veng 45.1% (n=31), Phnom Penh 40.2% (n=547) and Takeo 37.5% (n=32). For pig samples, all 9 FMD NSP sero-reactors were detected only in two provinces, namely Takeo at 1.0% (n=191) and Phnom Penh at abattoirs Boeng Salang (0.4%; n=245), Damnak Thum (1.6%; n=185), and Trea Boun (1%; n=295). The seropositive pigs originated from Kampong Speu (0.8%; 5/603) and Thailand (1.6%; 4/250). Only the cattle dataset was included in the risk factor analysis as the prevalence of sero-reactors was too low in the pig dataset to be analysed. Significant risk factors identified by the logistic regression model included province of origin (p=0.02), body condition score (BCS) (p=0.0002) and sex (p=0.0007). Odds ratios of the significant risk factors were 7.05 (95%CI 1.43-34.67; p=0.02) for cattle that originated from Kampong Thom, 1.41 (95%CI 1.05-1.89; p=0.02) for female cattle, and 3.28 (95% CI 1.06-10.12; p=0.04) for animals with BCS of 3/5. Conclusions: The study revealed that the seroprevalence of FMD NSP in cattle presenting at the abattoirs was high, while the FMD NSP seroprevalence in abattoir pigs was very low. Further investigation is required to map the disease distribution in Cambodia, especially the serotypes and strains causing clinical disease. These findings call for the extension of work on effective disease prevention measures, such as vaccination, early outbreak detection and movement restriction during outbreaks.

show abstract

Section: Discussioncontrasting

confidence: 60%

Foot-and-mouth disease Non-Structural Protein seropositivity in cattle and pigs in Cambodia

Kong

Siengsanan-Lamont

Tum

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Different vaccines, even with the same potency, have been seen to provide different levels of immunity and protection 41 . Vaccines used for FMD eradication in Europe stimulated high and long-lasting antibody levels for years after cattle had been vaccinated several times 3 42 43 , however, this may not be the case for other vaccines.…”

Section: Discussionmentioning

confidence: 99%

Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle

Knight-Jones

Gubbins

Bulut³

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Foot-and-mouth disease (FMD) in Turkey is controlled using biannual mass vaccination of cattle. However, vaccine protection is undermined by population turnover and declining immunity. A dynamic model of the Turkish cattle population was created. Assuming biannual mass vaccination with a single-dose primary course, vaccine history was calculated for the simulated population (number of doses and time since last vaccination). This was used to estimate population immunity. Six months after the last round of vaccination almost half the cattle aged <24 months remain unvaccinated. Only 50% of all cattle would have received >1 vaccine dose in their life with the last dose given ≤6 months ago. Five months after the last round of vaccination two-thirds of cattle would have low antibody titres (<70% protection threshold). Giving a two-dose primary vaccination course reduces the proportion of 6–12 month old cattle with low titres by 20–30%. Biannual mass vaccination of cattle leaves significant immunity gaps and over-reliance on vaccine protection should be avoided. Using more effective vaccines and vaccination strategies will increase population immunity, however, the extent to which FMD can be controlled by vaccination alone without effective biosecurity remains uncertain.

show abstract

“…Following infection, animals can remain seropositive to structural antibodies of FMDV for several years (Doel, 2005) and antibodies to the 3ABC NS protein have been found to be still detectable at 1–2 years after infection of experimental animals (Clavijo et al., 2004). Although FMD vaccination does not produce a long lasting protection, antibodies due to vaccination can be found several years after the cessation of vaccination, especially in multiply vaccinated animals (Remond et al., 2001; Terpstra et al, 1990). However, if vaccination had been the cause of the antibodies found it would not have been expected to have found so many animals with antibodies against both non‐structural and structural proteins of FMDV, since vaccination preferentially elicits antibodies to structural proteins.…”

Section: Discussionmentioning

confidence: 99%

Investigations into the Cause of Foot-and-Mouth Disease Virus Seropositive Small Ruminants in Cyprus During 2007

Paton

Ferris

Hutchings

et al. 2009

Transboundary and Emerging Diseases

View full text Add to dashboard Cite

In 2007, serological evidence for foot-and-mouth disease (FMD) infection was found as a result of differential diagnostic testing of Cypriot sheep suspected to be infected with bluetongue or contagious ecthyma. Seropositive sheep and goats were subsequently uncovered on ten geographically clustered flocks, while cattle and pigs in neighbouring herds were all seronegative. These antibodies were specific for serotype-O FMD virus, reacting with both structural and non-structural (NS) FMD viral proteins. However, no FMD virus could be recovered from the seropositive flocks. FMD had not been recorded in Cyprus since 1964 and there has been no vaccination programme since 1984. Since all the seropositive animals were at least 3 years old and home-bred, it was concluded that infection had occurred approximately 3 years previously had passed un-noticed and died out spontaneously. It therefore appears that antibodies to FMD virus NS proteins can still be detected around 3 years after infection of small ruminants, but that virus carriers cannot be detected at this time. This unusual situation of finding evidence of historical infection in a FMD-free country caused considerable disruption and alarm and posed questions about the definition of what constitutes a FMD outbreak.

show abstract

Residual foot-and-mouth disease virus antibodies in French cattle and sheep six years after the vaccination ban

Cited by 7 publications

References 8 publications

Foot-and-mouth disease Non-Structural Protein seropositivity in cattle and pigs in Cambodia

Foot-and-mouth disease Non-Structural Protein seropositivity in cattle and pigs in Cambodia

Mass vaccination, immunity and coverage: modelling population protection against foot-and-mouth disease in Turkish cattle

Investigations into the Cause of Foot-and-Mouth Disease Virus Seropositive Small Ruminants in Cyprus During 2007

Contact Info

Product

Resources

About