Design of diagnosis systems is a complex task that involves many different steps. Full understanding of all different parts of the design procedure requires deep knowledge on theory from a wide variety of subjects. Thus, to encourage the use of results from diagnosis research it is highly desirable to have software support in the design process. This paper describes ongoing work for determining an architecture for such a toolbox. The paper also describes software solutions in the toolbox. In industry as well as in universities, Matlab is probably the most widespread tool used by control engineers. Therefore the toolbox is primarily based upon Matlab but also some computer algebraic tools such as Mathematica and Maple are used.