Residual ground glass opacities three months after Covid-19 pneumonia correlate to alteration of respiratory function: The post Covid M3 study

Frija‐Masson, Justine; Debray, Marie‐Pierre; Boussouar, Samia; Khalil, Antoine; Bancal, Catherine; Motiejūnaitė, Justina; Galarza-Jimenez, Maria Alejandra; Benzaquen, Hélène; Penaud, D.; Laveneziana, Pierantonio; Malrin, Roxane; Redheuil, Alban; Donciu, Victoria; Lucidarme, Olivier; Taillé, Camille; Guerder, Antoine; Arnoult, Florence; Vidal‐Petiot, Emmanuelle; Flamant, Martin; Similowski, Thomas; Morélot-Panzini, Capucine; Faure, Morgane; Lescure, François-Xavier; Straus, Christian; d’Ortho, Marie-Pia; Gonzalez-Bermejo, Jésus

doi:10.1016/j.rmed.2021.106435

Cited by 42 publications

(30 citation statements)

References 22 publications

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“…Post-COVID-19 pulmonary fibrosis occurs together with various lesions, such as interstitial abnormalities including reticulation, irregular pleural interfaces, traction bronchiectases or even honeycomb lesions. These lesions are present in 13–27% of patients, depending on the series and the delay in evaluation [ 3 , 7 , 15 , 35 ]. The extent of the lesions is small to moderate, frequently involving <25% of the pulmonary parenchyma [ 7 ].…”

Section: Respiratory Disordersmentioning

confidence: 99%

Post-acute COVID-19 syndrome

et al. 2022

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Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic that has resulted in millions of deaths and a major strain on health systems worldwide. Medical treatments for COVID-19 (anticoagulants, corticosteroids, anti-inflammatory drugs, oxygenation therapy and ventilation) and vaccination have improved patient outcomes. The majority of patients will recover spontaneously or after acute-phase management, but clinicians are now faced with long-term complications of COVID-19 including a large variety of symptoms, defined as “post-acute COVID-19 syndrome”. Most studies have focused on patients hospitalised for severe COVID-19, but acute COVID-19 syndrome is not restricted to these patients and exists in outpatients. Given the diversity of symptoms and the high prevalence of persistent symptoms, the management of these patients requires a multidisciplinary team approach, which will result in the consumption of large amounts of health resources in the coming months. In this review, we discuss the presentation, prevalence, pathophysiology and evolution of respiratory complications and other organ-related injuries associated with post-acute COVID-19 syndrome.

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Section: Respiratory Disordersmentioning

confidence: 99%

Post-acute COVID-19 syndrome

et al. 2022

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“…Применение стероидов во время острой фазы не влияло на функцию легких или остаточные изменения в легких при МСКТ через 3 мес. после пневмонии COVID-19 [33]. По данным D.S.…”

Section: Discussionunclassified

Past COVID-19 infection and feasibility of transcatheter aortic valve replacement in a patient with severe aortic stenosis (a clinical case study)

2022

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A fatal case of severe stenosis of the aortic orifice in a patient with not diagnosed in time, long-term persistent covid infection is presented. The patient was hospitalized to resolve the issue of surgical correction of the aortic stenosis. On admission, there were symptoms of circulatory failure at the level of 3–4 functional class according to NYHA and angina pectoris clinic. A detailed collection of anamnesis about the epidemiological environment and symptoms of pneumonia suffered in the fall of 2020 raised suspicions of its covid genesis. Subsequently, this assumption was confirmed by the data of laboratory, instrumental studies, as well as the results of the pathological and anatomical autopsy. The study of microslides showed signs of extensive vasculitis with thrombosis of small branches of the pulmonary artery and foci of pneumofibrosis of various degrees of prescription, which also testified in favor of the transferred covid infection. Taking into account the severity of the patient’s condition upon admission, it was not possible to perform emergency intervention on the aortic valve. After stabilization of the state and regression of the phenomena of circulatory failure, it was planned to simultaneously perform endovascular revascularization of the coronary valve bed and transcatheter aortic valve replacement. The planned surgical intervention failed. The immunosuppressive effect of the SARS-CoV-2 virus, apparently, led to the activation of autoflora and an increase in inflammation for nosocomial infection. Bilateral polysegmental bacterial pneumonia that joined during hospitalization, against the background of postcoid changes in the lung parenchyma, contributed to the development of acute coronary syndrome with ventricular arrhythmias. The patient died from acute cardiopulmonary failure. The article also presents ideas about the operational tactics of managing patients with aortic stenosis in a pandemic.

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“…Considering the proven role of these echo parameters in assessing a decreased exercise capacity and increased dyspnoea in COPD patients [37], they might as well predict the outcome of patients after COVID-19 pneumonia. However, considering the contrasting evidence on the results of pulmonary function tests after SARS-CoV-2-related pneumonia [38,39], prospective and more powered studies are mandatory to define the abnormal thresholds, feasibility and diagnostic power of such echo imaging techniques in this patient population. Finally, future research is needed to determine the long-term persistence of COVID-19related cardiac and pulmonary sequelae, their clinical significance and impact on these patients and the potential modalities to prevent and treat such potentially life-threatening consequences [40].…”

Section: Discussionmentioning

confidence: 99%

Combined Use of Electrocardiography and Ultrasound to Detect Cardiac and Pulmonary Involvement after Recovery from COVID-19 Pneumonia: A Case Series

Marazzato

Ponti

Verdecchia³

et al. 2021

JCDD

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Background: Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may cause an acute multiorgan syndrome (coronavirus disease 2019 (COVID-19)), data are emerging on mid- and long-term sequelae of COVID-19 pneumonia. Since no study has hitherto investigated the role of both cardiac and pulmonary ultrasound techniques in detecting such sequelae, this study aimed at evaluating these simple diagnostic tools to appraise the cardiopulmonary involvement after COVID-19 pneumonia. Methods: Twenty-nine patients fully recovered from COVID-19 pneumonia were considered at our centre. On admission, all patients underwent 12-lead electrocardiogram (ECG) and transthoracic echocardiography (TTE) evaluation. Compression ultrasound (CUS) and lung ultrasound (LUS) were also performed. Finally, in each patient, pathological findings detected on LUS were correlated with the pulmonary involvement occurring after COVID-19 pneumonia, as assessed on thoracic computed tomography (CT). Results: Out of 29 patients (mean age 70 ± 10 years; males 69%), prior cardiovascular and pulmonary comorbidities were recorded in 22 (76%). Twenty-seven patients (93%) were in sinus rhythm and two (7%) in atrial fibrillation. Persistence of ECG abnormalities from the acute phase was common, and nonspecific repolarisation abnormalities (93%) reflected the high prevalence of pericardial involvement on TTE (86%). Likewise, pleural abnormalities were frequently observed (66%). TTE signs of left and right ventricular dysfunction were reported in two patients, and values of systolic pulmonary artery pressure were abnormal in 16 (55%, despite the absence of prior comorbidities in 44% of them). Regarding LUS evaluation, most patients displayed abnormal values of diaphragmatic thickness and excursion (93%), which correlated well with the high prevalence (76%) of pathological findings on CT scan. CUS ruled out deep vein thrombosis in all patients. Conclusions: Data on cardiopulmonary involvement after COVID-19 pneumonia are scarce. In our study, simple diagnostic tools (TTE and LUS) proved clinically useful for the detection of cardiopulmonary complications after COVID-19 pneumonia.

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Residual ground glass opacities three months after Covid-19 pneumonia correlate to alteration of respiratory function: The post Covid M3 study

Cited by 42 publications

References 22 publications

Post-acute COVID-19 syndrome

Post-acute COVID-19 syndrome

Past COVID-19 infection and feasibility of transcatheter aortic valve replacement in a patient with severe aortic stenosis (a clinical case study)

Combined Use of Electrocardiography and Ultrasound to Detect Cardiac and Pulmonary Involvement after Recovery from COVID-19 Pneumonia: A Case Series

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