“…These findings confirm our earlier reported data on the high prevalence of the c.-23+1G>A pathogenic variant among the Yakut population in Eastern Siberia [ 84 ]. Interestingly, in the Yakut patients, the second most common pathogenic variant was c.109G>A (p.Val37Ile), which was found with high frequency in Southeast Asia (Thailand, Indonesia, Malaysia) [ 41 , 47 , 48 ], East Asia (China, Korea, Japan) [ 33 , 35 – 38 , 40 , 42 , 44 , 46 ], and Australia [ 71 ], as well as among patients with HI of Asian origin in the US [ 87 ]. Pathogenic variants с.35delG (22.34%), c.-23+1G>A (5.31%), and c.313_326del14 (2.12%) were the most frequent in the group of Russian patients.…”