Residual Intestinal Disease After Milk Allergy in Infancy

Kokkonen, Jorma; Tikkanen, S; Savilahti, Erkki

doi:10.1097/00005176-200102000-00012

Cited by 41 publications

(24 citation statements)

References 16 publications

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“…The first abates, while the latter does not, at least not in all patients, the reactivity persisting on the mucosa of the GI tract giving only GI symptoms and mainly no skin or other symptoms [10,11]. We speculate that in the present material the increase in GI symptoms may be partly due to this reactivity, though we did not test these subjects.…”

Section: Discussionmentioning

confidence: 52%

“…There is now increasing evidence showing that subjects with untreated food allergy have the same type of skewing of the immune response as those with celiac disease (CD), a state increasing the risk of autoimmune disorders [7][8][9]. Moreover, we recently found that food allergy in infancy does not remit as was previously believed, the immune reactivity on the mucosa of the gastrointestinal tract apparently remaining [10,11]. Following these observations we hypothesized that the subjects with infantile onset atopic dermatitis, like subjects with CD, might be at risk of eventually manifesting autoimmune and/or immune-mediated GI disorders more than expected.…”

Section: Introductionmentioning

confidence: 99%

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Increased incidence of autoimmune disorders as a late complication in children with early onset dermatitis and/or milk allergy

Kokkonen

Niinimäki

2004

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Increased incidence of autoimmune disorders as a late complication in children with early onset dermatitis and/or milk allergy

Kokkonen

Niinimäki

2004

Journal of Autoimmunity

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“…Many autoimmune diseases have in common many of the features of the immune response with atopic disorders [23,24]. Moreover, they found that food allergy in infancy does not remit the immune reactivity on the mucosa of the gastrointestinal tract [25,26]. So the persistent and exaggerated immune response on the gastrointestinal mucosa and related lymphoproliferative system due to untreated food allergy could be the central pathogenic mechanism for this co-occurrence.…”

Section: Discussionmentioning

confidence: 99%

Anticardiolipin antibodies in children with atopic dermatitis

Ricci

Maldini

Patrizi

et al. 2005

Journal of Autoimmunity

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“…This is still the object of numerous studies on the youngest children with food hypersensitivity and GER, whereas in older children with persistent allergy [1,13,14,16,22,25,27,28].…”

Section: Introductionmentioning

confidence: 99%

Histological evaluation of esophageal mucosa in children with acid gastroesophageal reflux.

Semeniuk

Kaczmarski²,

Uścinowicz³

et al. 2009

Folia Histochem Cytobiol.

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AIM: histological evaluation of esophageal mucosa in children, with regard to the duration of primary acid gastroesophageal reflux (GER) and acid GER secondary to cow's milk allergy and/or other food allergy (CMA/FA) (prospective study). MATERIAL AND METHODS: 264 children of both sexes suspected of GER were enrolled in the study. The age of examined children was 1.5-102 months, mean age 20.78±17.23 months. Pathological acid GER was confirmed with pH-monitoring in 138 children (52.3%). Taking into consideration complex differential diagnosis, including oral food challenge test with potentially noxious nutrient (open or blind study), children were assigned into study groups 1 and 2 (primary and secondary GER). Group 1: 76 patients (28.8%) aged 4-102 months (x=25.2±27.28 months) with primary GER. Group 2: 62 patients (23.5%) aged 4-74 months (x=21.53±17.79 months) with GER secondary to CMA/FA. Children with GERD underwent preliminary and control (after 1 year and 2 years of GERD diagnosis) endoscopic examination of the upper gastroinestinal tract. RESULTS: Intensity of esophagitis was assessed initially in 25 children from group 1 (32.9%), in 29 children from group 2 (46.8%), and in 9 children from group 3 -reference group (28.1%). Histological evaluation revealed infiltration of inflammatory cells, mainly neutrophils and intraepithelial lymphocytes, and also eosinophils in 10 children (13.2%) with primary GER. Infiltration of eosinophils and lymphocytes was found in 5 children (8.1%) with secondary GER. In 8 children (25.0%) with food allergy there were only lymphocytes. Infiltration of neutrophils and lymphocytes and basal zone hyperplasia or infiltration of eosinophils and lymphocytes with elongation of lamina propria papillae was found in 10 children (13.1%) with primary GER and in 20 children (32.2%) with secondary GER. Differentiation of particular types of inflammatory cells in mucosal infiltration characterized histological picture in the following way: neutrophils in 21 children (27.6%) with primary GER, eosinophils in 22 children (35.5%) with secondary GER, lymphocytes in 15 children (19.7%) in children with primary GER and in 15 children (24.2%) with secondary GER. Histological examination of esophageal mucosa after 1 and 2 years of clinical observation and periodical conservative treatment in children with primary and secondary GER revealed significant alleviation of inflammatory abnormalities (with regard to the type of abnormalities and the number of particular types of inflammatory cells). CONCLUSIONS: The value of histological findings obtained in own studies comprises the role of food allergy in pathogenesis of GER and is related to GER's contribution, both direct (primary reflux) and indirect (secondary reflux), to triggering off morphological results and clinical outcomes of esophagitis.

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Residual Intestinal Disease After Milk Allergy in Infancy

Cited by 41 publications

References 16 publications

Increased incidence of autoimmune disorders as a late complication in children with early onset dermatitis and/or milk allergy

Increased incidence of autoimmune disorders as a late complication in children with early onset dermatitis and/or milk allergy

Anticardiolipin antibodies in children with atopic dermatitis

Histological evaluation of esophageal mucosa in children with acid gastroesophageal reflux.

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