A series of experiments were carried out to study the relationship between polymer and reservoir permeability, as well as the alternating injection pattern for heterogeneous formations. The polymer molecular size (MS) was studied using dynamic light scattering. The parameters such as hydraulic radius, molecular weight (MW), concentrations and salinity were studied. The injection capacity and the relationship between polymer and formation were obtained using injection experiments with natural cores, which represent different regions in the Daqing oilfield. Moreover, an improved injection pattern, alternating injection in heterogeneous formation was studied based on the injection experiments of parallel and in-layer heterogeneous artificial cores. The alternate cycle and slug size were investigated. It was proven that the alternating injection can improve the efficiency of low permeability layers up to 7.3% and a mean value of 4.27%. It was also found that the mechanism of alternating injection is blocking the high permeability layers and improving the water injection profile. We suggest that other fields with high heterogeneity could try the alternating injection to optimize the polymer flooding. Meanwhile, further pilot tests or numerical simulation of polymer alternating injection in heterogeneous formation (formation type II) should be conducted.