Residual risk and retrospective analysis of transfusion‐transmitted bacterial infection reported by the <scp>F</scp>rench <scp>N</scp>ational <scp>H</scp>emovigilance <scp>N</scp>etwork from 2000 to 2008

Lafeuillade, Bruno; Eb, F.; Ounnoughène, N.; Petermann, Rachel; Daurat, G.; Huyghe, Gérard; Vo, Mai-Phuong; Caldani, C.; Rebibo, Danielle; Weinbreck, P.

doi:10.1111/trf.12883

Cited by 41 publications

(57 citation statements)

References 48 publications

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“…Use of active surveillance of patients by dedicated hemovigilance personnel has been shown to improve recognition of STRs. 19 We also noted that STRs occurred with high bacterial loads only when patients were neutropenic (white blood cell [WBC] count ,2 3 10 9 /L), likely related to the relatively low virulence of the gram-positive contaminants transfused. However, we did not find any evidence of delayed sequela resulting from transfusion of contaminated platelets.…”

Section: Discussionmentioning

confidence: 99%

“…4,5,[17][18][19][20] Despite the recognition of these complications of platelet transfusion, their true incidence is unknown as a result of underdetection and underreporting, notwithstanding improved hemovigilance programs. A recent report on transfusion-associated circulatory overload showed considerable underreporting, with a 36-fold difference in detection between active and passive surveillance: 1:5997 cases reported by passive surveillance vs 1:167 by active surveillance.…”

Section: Discussionmentioning

confidence: 99%

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Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

Hong

Xiao

Lazarus

et al. 2016

Blood

174

230

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• Bacterial sepsis from contaminated platelet transfusions continues to occur despite recent interventions; additional measures are needed.• STR to platelet transfusion is frequently not recognized or reported; use of recent AABB criteria showed highest diagnostic sensitivity.Septic transfusion reactions (STRs) resulting from transfusion of bacterially contaminated platelets are a major hazard of platelet transfusion despite recent interventions. Active and passive surveillance for bacterially contaminated platelets was performed over 7 years (2007)(2008)(2009)(2010)(2011)(2012)(2013) by culture of platelet aliquots at time of transfusion and review of reported transfusion reactions. All platelet units had been cultured 24 hours after collection and released as negative. Five sets of STR criteria were evaluated, including recent AABB criteria; sensitivity and specificity of these criteria, as well as detection by active and passive surveillance, were determined. Twenty of 51 440 platelet units transfused (0.004%; 389 per million) were bacterially contaminated by active surveillance and resulted in 5 STRs occurring 9 to 24 hours posttransfusion; none of these STRs had been reported by passive surveillance. STR occurred only in neutropenic patients transfused with high bacterial loads. A total of 284 transfusion reactions (0.55%) were reported by passive surveillance. None of these patients had received contaminated platelets. However, 6 to 93 (2.1%-32.7%) of these 284 reactions met 1 or more STR criteria, and sensitivity of STR criteria varied from 5.1% to 45.5%. These results document the continued occurrence of bacterial contamination of platelets resulting in STR in neutropenic patients, failure of passive surveillance to detect STR, and lack of specificity of STR criteria. These findings highlight the limitations of reported national STR data based on passive surveillance and the need to implement further measures to address this problem such as secondary testing or use of pathogen reduction technologies. (Blood. 2016;127(4):496-502)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

Hong

Xiao

Lazarus

et al. 2016

Blood

174

230

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“…This essay will not further discuss such cases. Neither will it discuss the specific case of bacterial contamination of PCs, largely related to the storage temperature of 22 ± 2°C; 18.5 severe cases per million PCs delivered are recorded annually according to the latest French hemovigilance records; and one such case happens to be lethal, on average (30). …”

Section: The Major Identified Causes Of Transfusion-associated Inflammentioning

confidence: 99%

Transfusion as an Inflammation Hit: Knowns and Unknowns

et al. 2016

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Transfusion of blood cell components is frequent in the therapeutic arsenal; it is globally safe or even very safe. At present, residual clinical manifestations are principally inflammatory in nature. If some rare clinical hazards manifest as acute inflammation symptoms of various origin, most of them linked with conflicting and undesirable biological material accompanying the therapeutic component (infectious pathogen, pathogenic antibody, unwanted antigen, or allergen), the general feature is subtler and less visible, and essentially consists of alloimmunization or febrile non-hemolytic transfusion reaction. The present essay aims to present updates in hematology and immunology that help understand how, when, and why subclinical inflammation underlies alloimmunization and circumstances characteristic of red blood cells and – even more frequently – platelets that contribute inflammatory mediators. Modern transfusion medicine makes sustained efforts to limit such inflammatory hazards; efforts can be successful only if one has a clear view of each element’s role.

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“…Due to the control of viral risk, transfusion‐transmitted bacterial infections (TTBIs) are the main residual infectious complications of transfusion and the major cause of mortality related to BCs . The incidence of severe TTBI was estimated at 1.6 per million transfused BCs during the 2000 to 2008 period . Gram‐negative bacteria are the main bacteria involved in serious episodes of TTBI and Escherichia coli ranks first among them .…”

mentioning

confidence: 99%

“…The incidence of severe TTBI was estimated at 1.6 per million transfused BCs during the 2000 to 2008 period . Gram‐negative bacteria are the main bacteria involved in serious episodes of TTBI and Escherichia coli ranks first among them . Platelet concentrates (PCs) are the primary sources of TTBI.…”

mentioning

confidence: 99%

Genotypic and phenotypic characteristics of Escherichia coli involved in transfusion‐transmitted bacterial infections: implications for preventive strategies

et al. 2018

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Residual risk and retrospective analysis of transfusion‐transmitted bacterial infection reported by the French National Hemovigilance Network from 2000 to 2008

Cited by 41 publications

References 48 publications

Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance

Transfusion as an Inflammation Hit: Knowns and Unknowns

Genotypic and phenotypic characteristics of Escherichia coli involved in transfusion‐transmitted bacterial infections: implications for preventive strategies

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