Residual risk of transfusion-transmitted infection with human immunodeficiency virus, hepatitis C virus, and hepatitis B virus in Korea from 2000 through 2010

Kim, Moon Jung; Park, Quehn; Min, Hyuk Ki; Kim, Hyun Ok

doi:10.1186/1471-2334-12-160

Cited by 39 publications

(38 citation statements)

References 24 publications

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“…If minipool NAT and anti‐HCV are used together, with an infectious window period of 7.4 days, the NAT should reduce the residual risk to 2 per million units transfused, an eightfold decrease that would bring the residual risk of HCV transmission in China closer to those in the developed countries. Yet it will still be higher than that in Korea (1 in 2,984,415) but lower than in Brazil and countries in sub‐Saharan Africa (2.5 per 1000 units transfused) …”

Section: Discussionmentioning

confidence: 76%

The persistence of hepatitis C virus transmission risk in China despite serologic screening of blood donations

et al. 2013

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Section: Discussionmentioning

confidence: 76%

The persistence of hepatitis C virus transmission risk in China despite serologic screening of blood donations

et al. 2013

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“…Prevalence of anti-HCV showed declining trend in Korea and Germany but has been stable in the last 20 years in Poland [32,33,35]. Seroprevalence of HCV and HIV differ over time among different categories of blood donors as declining trend was observed among first time donors while prevalence remain stable among repeat blood donors [36,37,38]. A seroprevalence of 0.6 and 0.4% in 2009 and 2010 which peaked to 3.6% in 2014 is alarming and should be viewed seriously.…”

Section: Discussionmentioning

confidence: 99%

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Fasola¹

2017

CMR

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Africa has the highest prevalence of transfusion transmitted infections. The World Health Organization recommends universal and quality-controlled screening of blood donations for the major transfusion-transmissible infections (TTIs): human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis. Therefore a retrospective study was conducted to assess the effect of strategies in our blood bank to improve blood safety on the seroprevalence of HIV, HCV, HBV and syphilis infections among the donors over a seven year period. Existing data in the blood bank was used to determine number of the blood donors who were infected with HIV, HCV, HBV and syphilis. The test methods used to screen the donors were identified. The trend of prevalence of the transfusion transmitted infections among the blood donors from 2009 to 2015 was also determine. A total of 41,445 blood donors were screened. Voluntary blood donors constituted 11.1% of the donor population. The overall seroprevalence rate for the TTI was 12.3%. The prevalence was highest for HBV (8.5%) followed by HIV (1.8%), HCV (1.4%) and least for syphilis (0.5%) respectively. The infections showed significant inter-year variation (p<.001). A decreasing trend was observed for HBV among the blood donors while increase in prevalence of HIV, HCV and syphilis was observed from 2012 to 2014 and decreased in 2015. The prevalence of syphilis has risen from 0% in 2009 to 0.9% in 2015. The seroprevalence for TTI is high but is less compared to report from a previous study in same blood bank. The increasing infection rate for syphilis and sporadic surges in rates for HIV, HCV may suggest that the selection criteria is not effectively eliminating blood donors with risky lifestyle. There is need to educate the blood donors on avoiding risky lifestyle while also intensifying voluntary blood donor motivation strategy and increase community surveillance of the infections.

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“…In the Republic of Korea, the HBV residual risk remained stable during the 2000 decade, with 1 : 45.896 in the beginning and 1 : 43.666 by the end of the decade [54]. The first-time donors' HBV incidence was about 20 times higher than in the repeat donors.…”

Section: Developed Countriesmentioning

confidence: 96%

Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

Kupek

2013

ISRN Infectious Diseases

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Despite a considerable reduction of the risk of HBV-infected blood donation entering blood supply (residual risk) due to improved screening by HBV NAT in the developed countries, the bulk of the people with HBV living in the developing countries still needs to be screened by serologic tests such as HBsAg and anti-HBc. Many of these countries lack resources for implementing NAT and are likely to remain so in the next decade or longer, thus depending on the HBV residual risk monitoring based on serologic testing and corresponding estimation methods. This paper reviews main HBV residual risk findings worldwide and the methods based on serology used for their calculation with repeat donors, as well as their extension to the first-time donors. Two artificial datasets with high (4.36%) and low (0.48%) HBV prevalence were generated to test the performance of five methods: the original incidence/window-period model based solely on HBsAg, its modification by Soldan in 2003, the Müller-Breitkreutz model, the HBsAg yield model, and its extension to include anti-HBc seroconversions within a year. The last model was closest to the true values of residual risk and had smallest variation of the estimates in both high and low prevalence data. It may be used for residual risk evaluation in relatively small samples, such as regional blood banks data.

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Residual risk of transfusion-transmitted infection with human immunodeficiency virus, hepatitis C virus, and hepatitis B virus in Korea from 2000 through 2010

Cited by 39 publications

References 24 publications

The persistence of hepatitis C virus transmission risk in China despite serologic screening of blood donations

The persistence of hepatitis C virus transmission risk in China despite serologic screening of blood donations

A Seven Year Review of the Seroprevalence of Transfusion Transmitted Infections in a Hospital Based Blood Bank in Ibadan, Nigeria

Residual Risk of Hepatitis-B-Infected Blood Donations: Estimation Methods and Perspectives

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