This research investigates the fatigue behaviour and fracture mechanics of high-performance concrete (HPC), including various compositions such as HPC with basalt aggregates (HPC-B), HPC with gravel (HPC-G), and high-strength coarse mortar (CM) under static and cyclic tensile loading within the special priority program SPP 2020. The study aims to integrate fracture mechanics into structural analysis to enhance design guidelines for slender cross-sections and safety-related high-performance structural components. The experimental investigations reveal HPC-B’s remarkable superiority, displaying its higher compressive strength, modulus of elasticity, and tensile strength compared to HPC-G and CM. A modified disk-shaped compact tension (MDCT) based on ASTM standards, aided by digital image correlation (DIC) unveils fracture behaviour, emphasizing fracture energy as a crucial parameter. HPC-B exhibits improved crack resistance and notch sensitivity reduction attributed to crushed basalt aggregates and an enhanced interfacial transition zone (ITZ). The research scrutinizes factors like material characterization, aggregate morphology, stress levels, and the displacement rate on crack formation. High-cycle fatigue tests show HPC-B’s superior performance, and the post-fatigue analysis reveals enhanced residual fracture toughness attributed to nano-level structural changes, stress redistribution and aggregate-matrix interaction. A 3D image analysis via Computed Tomography (CT) scans captures mesostructural crack propagation and provide quantitative insights. This research marks a significant shift from conventional aggregate-focused approaches and introduces a novel approach by integrating excess paste theory and mesoscale analysis, highlighting the critical role of aggregate choice in material characterization and mesoscale design in enhancing the structural efficiency of HPC. Furthermore, the study advances the understanding of HPC fatigue behaviour, emphasizing the interplay of aggregate types and morphologies and their dynamic response to cyclic loading, offering valuable insights for optimizing design guidelines and fostering innovation in structural engineering.