Residual veterinary antibiotics in pig excreta after oral administration of sulfonamides

Abstract

Sulfonamides (SAs) are applied widely as feed additives in the farming of livestock and poultry. It can lead to the excretion of large amounts of SAs in manure and result in persistent environmental pollution. We evaluated the fate of four SAs, sulfamerazine (SM1), sulfachloropyridazine (SCP), sulfadimoxine (SDM') and sulfaquinoxaline (SQ), from oral administration to excretion in urine and feces in pigs. The four SAs were added to homemade feed to make them reach the required concentration gradient, which were 0, 50 and 100 mg/kg (low, normal and high concentrations, respectively). In different treatments, excretions of the four SAs were 35.68-86.88 %. With regard to total excretion, the order was SQ > SCP > SM1 > SDM' for all treatments. The concentration of SAs in the feed had significant effects on the amount of the four SAs excreted every day. The concentration of SAs in feces and in the urine for different treatments was 15.03-26.55 and 14.54-69.22 %, respectively. In each treatment, excretions of SCP, SDM' and SQ in feces were lower than that in urine. The four SAs remained longer in urine than in feces. Excretions in urine and feces were lower if SAs were administered orally rather than by injection.

Swine Manure Composting With Compound Microbial Inoculants: Removal of Antibiotic Resistance Genes and Their Associations With Microbial Community

“…With the rapid development of intensive culture, antibiotics have been widely used in feed for promoting growth and for disease prevention purposes. However, antibiotics in animal tissues are absorbed incompletely; parts of antibiotics are excreted in urine and feces (Qiu et al, 2016). Antibiotic residues cause serious pollution to the environment, pose a threat to human health, and even have toxic side effects (Sarmah et al, 2006).…”

Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia

“…Veterinary drugs are mainly divided into antibiotics, hormones, and anthelmintics. Antibiotics are the main veterinary drug additives, accounting for 60% of the total veterinary drugs [17][18][19]. Extensive use of veterinary drugs not only affects the quality and safety of animal products but also damages the health of consumers due to the drug residues.…”

Determination of sulfadimethoxine in milk with aptamer‐functionalized Fe3O4/graphene oxide as magnetic solid‐phase extraction adsorbent prior to HPLC

“…Sulfadimethoxine (SDM) is widely used to prevent and treat poultry diseases caused by bacterial infection [1]. The residues of SDM have been found in food [2] and environmental water samples [3], which not only cause continuous pollution to the environment [4], but also have potential carcinogenic risk to human body [5], leading to antibiotic resistance and increasing the difficulty of antibiotic utilization. The maximum residue limit of SDM in animal derived food set by the European Commission was 100 µg/L [6].…”