The article presents a new method of determining the residual water saturation of the Bazhenov Rock Formation using synchronous thermal analysis which is combined with gas IR and MS spectroscopy. The efficiency of the extraction-distillation method of determining open porous and residual saturation in comparison with the developed method which are considered in detail. Based on the results of studies in the properties of the Bazhenov Rock Formation, a significant underestimation of the residual water saturation in the existing guidelines for calculating reserves was found, and the structure of the saturation of rocks occurred to be typical for traditional low-permeability reservoirs. The values of open porous and residual water saturation along the section of the Bazhenov Formation vary greatly, which also contradicts the well-established opinion about the weak variability of the rock properties with depth.