Residue analysis of penicillines in livestock and marine products

Song, Ji-Young; Hu, Soojung; Joo, Hyunjin; Kim, Miok; Hwang, Joung-Boon; Han, Yoon-Jung; Kwon, Yu-Jihn; Kang, Shin-Jung; Cho, Dae‐Hyun

doi:10.5806/ast.2012.25.4.257

Analytical Science and Technology

2012

DOI: 10.5806/ast.2012.25.4.257

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Residue analysis of penicillines in livestock and marine products

Ji-Young Song¹,

Soojung Hu²,

Hyunjin Joo³

et al.

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Cited by 4 publications

(1 citation statement)

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“…AMOX에 관해 국내에서 연구된 보고에 따르면 정 등 (Jung et al, 2006), 김 등 (Kim et al, 2009), 전 등 (Seo et al, 2010), 송 등 (Song et al, 2012) Abbreviation: h, hours; t1/2ka, half-life of the drug during absorbance; t1/2α, half-life of the drug during distribution phase; t1/2β, half-life of the drug during elimination phase; tmax, time for maximum concentration; Cmax, the maximum concentration; AUC0-∞, area under the time-concentration curve; MRT, mean residence time. (Jung et al, 2008).…”

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confidence: 99%

Pharmacokinetics of amoxicillin after intramuscular injection at different temperatures to cultured olive flounder, Paralichthys olivaceus

Kim¹,

Lee²,

Lee³

et al. 2015

Journal of fish pathology

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The pharmacokinetic properties and residue levels of amoxicillin (AMOX) were studied after intramuscular injection to cultured olive flounders (100±50 g), Paralichthys olivaceus. For pharmacokinetic studies, AMOX of 20 to 80 mg/kg body weight was administered at 17±2℃ or 22±2℃ and AMOX concentrations were determined in plasma, the liver, and the kidney by HPLC-UVD. Plasma samples were assessed at 0.25, 0.5, 1, 3, 6, 12, 24, 48, 72, 96, 168 hours post-dose, whereas liver and kidney concentrations were measured at 0.25 to 48 hours post-dose. The kinetic profiles of AMOX were analyzed by fitting to a 2-compartmental model with PKSolver program. The following parameters were obtained for a single dosage of 20, 40 and 80 mg/kg of body weight at 22℃ and 20 and 40 mg/kg of body weight at 17℃ in plasma, liver and kidney, respectively: Cmax (the peak concentration)= 27.23-257.36 ㎍/㎖, 5.49-41.65 ㎍/g, 16.75-129.31 ㎍/g; tmax (the time for peak concentration)= 0.05-0.91, 1.36-3.28, 1.95-4.49 h. For residue studies, AMOX of 40 and 400mg/kg was administered, and muscle samples were taken at 2, 5, 7, 14 and 21 days post-dose. The residueof AMOX in the muscle were found under the MRLs (maximum residue levels) within 7 days for the two doses.

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mentioning

confidence: 99%

Pharmacokinetics of amoxicillin after intramuscular injection at different temperatures to cultured olive flounder, Paralichthys olivaceus

Kim¹,

Lee²,

Lee³

et al. 2015

Journal of fish pathology

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Monitoring of Veterinary Drug Residues in Cultured Olive Flounder Paralichthys olivaceus from Jeju and Wando Regions

Seo¹,

Jo²,

Jeong³

et al. 2019

JFMSE

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Simultaneous Determination of Penicillin Antibiotics in Meat using Liquid Chromatography Tandem Mass Spectrometry

Kim¹,

Yoon²,

Kim³

et al. 2014

Journal of Food Hygiene and Safety

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The objective of this study was to develop a simultaneous method of 8 penicillin antibiotics including amoxicillin, ampicillin, cloxacillin, dicloxacillin, nafcillin, oxacillin, penicillin G and penicillin V in meat using LC-MS/MS. The procedure involves solid phase extraction with HLB cartridge and subsequent analysis by LC-MS/ MS. To optimize MS analytical condition of 8 compounds, each parameter was established by multiple reaction monitoring in positive ion mode. The chromatographic separation was achieved on a C 18 column with a mobile phase of 0.05% formic acid and 0.05% formic acid in acetonitrile at a flow rate of 0.2 mL/min for 20 min with a gradient elution. The developed method was validated for specificity, linearity, accuracy and precision in beef, pork and chicken. The recoveries were 71.0~106%, and relative standard deviations (RSD) were 4.0~11.2%. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.003~0.008 mg/kg and 0.01~0.03 mg/kg, respectively, that are below maximum residue limit (MRL) of the penicillins. This study also performed survey of residual penicillin antibiotics for 193 samples of beef, pork and chicken collected from 9 cities in Korea. Penicillins were not found in all the samples except a sample of pork which contained cloxacillin (concentration of 0.08 mg/kg) below the MRL (0.3 mg/kg).

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Residue analysis of penicillines in livestock and marine products

Cited by 4 publications

References 5 publications

Pharmacokinetics of amoxicillin after intramuscular injection at different temperatures to cultured olive flounder, Paralichthys olivaceus

Pharmacokinetics of amoxicillin after intramuscular injection at different temperatures to cultured olive flounder, Paralichthys olivaceus

Monitoring of Veterinary Drug Residues in Cultured Olive Flounder Paralichthys olivaceus from Jeju and Wando Regions

Simultaneous Determination of Penicillin Antibiotics in Meat using Liquid Chromatography Tandem Mass Spectrometry

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