Residue determination of dichlorvos and related metabolites in animal tissue and fluids

Schultz, D. R.; Marxmiller, Ronald L.; Koos, Bela A.

doi:10.1021/jf60178a042

Cited by 23 publications

(11 citation statements)

References 4 publications

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“…The aldehyde then is converted enzymatically to either dichloroethanol or dichloroacetic acid. Schultz et al (1971) and Wright et al (1979) proposed that these were products formed from dichlorvos by mammalian tissue. Eto (1974) suggested that dichloroacetaldehyde was formed nonenzymatically from dichlorvos.…”

Section: Resultsmentioning

confidence: 99%

Microbial and nonenzymic steps in the decomposition of dichlorvos (2,2-dichlorovinyl O,O-dimethyl phosphate)

Lieberman¹,

Alexander²

1983

J. Agric. Food Chem.

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Section: Resultsmentioning

confidence: 99%

Microbial and nonenzymic steps in the decomposition of dichlorvos (2,2-dichlorovinyl O,O-dimethyl phosphate)

Lieberman¹,

Alexander²

1983

J. Agric. Food Chem.

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“…The method described is sufficiently sensitive for measurement of plasma concentrations of DCA in clinical studies [3].…”

Section: Resultsmentioning

confidence: 99%

“…Lukas et al [2] describe a modification of this method. Schultz et al [3] were able to determine DCA after esterification with diazomethane. However, very acidic extraction conditions and no internal standard were used.…”

Section: Senello [L]mentioning

confidence: 99%

Determination of dichloroacetic acid in plasma and urine

Heizmann

Alten

1979

J. High Resol. Chromatogr.

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“…Recently, the use of GC coupled to mass spectrometry (MS) has been considered a suitable approach to improve selectivity and sensitivity (Grimalt et al ., 2006) ; it is thermally labile and decomposes when analyzed by GC using a heated injector (Ngoh and Cullison, 1996) . Analysis of trichlorfon residues has been reported using gas chromatography coupled with FID (Talebpour et al ., 2006) ; FPD (Iwata et al ., 1979 ; Sheets et al ., 1982 ; Maitlen and Halfhill, 1985) ; NPD (Schultz et al ., 1971 ; Ngoh and Cullison, 1996) and mass spectrometry (Aroa et al ., 2002 ; Brito et al ., 2002 ; Talebpour et al ., 2006) , and by high performance liquid chromatography (HPLC) (Arao et al ., 2002 ; Talebpour et al ., 2006 ; Zhu et al ., 2008) .…”

Section: Introductionmentioning

confidence: 99%

Determination of Trichlorfon Pesticide Residues in Milk via Gas Chromatography with μ-Electron Capture Detection and GC-MS

Hem¹,

Khay²,

Choi³

et al. 2010

Toxicological Research

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The pesticide trichlorfon is readily degraded under experimental conditions to dichlorvos. A method has therefore been developed by which residues of trichlorfon in milk are determined as dichlorvos, using gas chromatography with μ-electron capture detection. The identification of dichlorvos was confirmed by mass spectrometry. Milk was extracted with acetonitrile followed by centrifugation, freezing lipid filtration, and partitioning into dichloromethane. The residue after partitioning of dichloromethane was dissolved in ethyl acetate for gas chromatography. Recovery concentration was determined at 0.5, 1.0, and 2.0 of times the maximum permitted residue limits (MRLs) for trichlorfon in milk. The average recoveries (n = 6) ranged from 92.4 to 103.6%. The repeatability of the measurements was expressed as relative standard deviations (RSDs) ranging from 3.6%, to 6.7%. Limit of detection (LOD) and limit of quantification (LOQ) were 3.7 and 11.1 μg/l, respectively. The accuracy and precision (expressed as RSD) were estimated at concentrations from 25 to 250 μg/l. The intra- and inter-day accuracy (n = 6) ranged from 89.2%to 91% and 91.3% to 96.3%, respectively. The intra- and inter-day precisions were lower than 8%. The developed method was applied to determine trichlorfon in real samples collected from the seven major cities in the Republic of Korea. No residual trichlorfon was detected in any samples.

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Residue determination of dichlorvos and related metabolites in animal tissue and fluids

Cited by 23 publications

References 4 publications

Microbial and nonenzymic steps in the decomposition of dichlorvos (2,2-dichlorovinyl O,O-dimethyl phosphate)

Microbial and nonenzymic steps in the decomposition of dichlorvos (2,2-dichlorovinyl O,O-dimethyl phosphate)

Determination of dichloroacetic acid in plasma and urine

Determination of Trichlorfon Pesticide Residues in Milk via Gas Chromatography with μ-Electron Capture Detection and GC-MS

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