Residue profiles of brodifacoum in coastal marine species following an island rodent eradication

Masuda, Bryce; Fisher, Penny; Beaven, Brent

doi:10.1016/j.ecoenv.2014.11.013

Cited by 37 publications

(22 citation statements)

References 20 publications

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“…First, if the species is eaten by human [67,78], the consequences are comparable to those discussed for farm animals. Second, if the exposition is suiciently important, it might lead to intoxication of the animals and to its death, which can be problematic mainly for endangered species.…”

Section: Wildlife Exposures and Intoxicationmentioning

confidence: 67%

See 1 more Smart Citation

Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences

Lefebvre¹,

Fourel²,

Queffélec³

et al. 2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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Anticoagulant rodenticides (ARs) are a keystone of the management of rodent populations in the world. The widespread use of these molecules raises questions on exposure and intoxication risks, which deine the safety of these products. Exposures and intoxications can afect humans, domestic animals and wildlife. Consequences are diferent for each group, from the simple issue of intoxication in humans to public health concern if farm animals are exposed. After a rapid presentation of the mechanism of action and the use of anticoagulant rodenticides, this chapter assesses the prominence of poisoning by anticoagulant rodenticides in humans, domestic animals and wildlife.

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Section: Wildlife Exposures and Intoxicationmentioning

confidence: 67%

“…Exposition of ish was reported near an island where an eradication of rodent with brodifacoum was performed and the risk for human through the consumption appeared very low [78]. These intoxications may be primary when non-target species eat directly the bait.…”

Section: Wildlife Exposures and Intoxicationmentioning

confidence: 99%

Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences

Lefebvre¹,

Fourel²,

Queffélec³

et al. 2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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show abstract

“…In addition, recent studies have shown that ARs can be detected not only in shorebirds and seabirds, but also in marine biota, including fish, crabs, sea urchins, and shellfish [30, 38]. These papers suggest exposure pathways for ARs from marine biota to shorebirds and/or seabirds, and from shorebirds and seabirds to raptors.…”

Section: Exposure Pathwaysmentioning

confidence: 99%

A review: poisoning by anticoagulant rodenticides in non-target animals globally

Nakayama

Morita

Ikenaka

et al. 2019

The Journal of Veterinary Medical Science

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Worldwide use of anticoagulant rodenticides (ARs) for rodents control has frequently led to secondary poisoning of non-target animals, especially raptors. In spite of the occurrence of many incidents of primary or secondary AR-exposure and poisoning of non-target animals, these incidents have been reported only for individual countries, and there has been no comprehensive worldwide study or review. Furthermore, the AR exposure pathway in raptors has not yet been clearly identified. The aim of this review is therefore to comprehensively analyze the global incidence of primary and secondary AR-exposure in non-target animals, and to explore the exposure pathways. We reviewed the published literature, which reported AR residues in the non-target animals between 1998 and 2015, indicated that various raptor species had over 60% AR- detection rate and have a risk of AR poisoning. According to several papers studied on diets of raptor species, although rodents are the most common diets of raptors, some raptor species prey mainly on non-rodents. Therefore, preying on targeted rodents does not necessarily explain all causes of secondary AR-exposure of raptors. Since AR residue-detection was also reported in non-target mammals, birds, reptiles and invertebrates, which are the dominant prey of some raptors, AR residues in these animals, as well as in target rodents, could be the exposure source of ARs to raptors.

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“…There is also a significant risk of unintentional exposure to superwarfarins as a result of their use to eradicate rodents. A recent review of 10 aerial BDF dispersals in New Zealand and the United States showed that BDF was detected in 11 of 196 (5.6%) marine invertebrate samples tested, and in two of 65 (3.1%) fish samples up to 176 days after application. BDF poisoning outbreaks due to accidental leakage are an increasing possibility with potentially devastating consequences.…”

Section: The Emerging Threat Of Superwarfarins: Unintentional Exposurementioning

confidence: 99%

The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures

Feinstein

Akpa

Ayee

et al. 2016

Annals of the New York Academy of Sciences

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Superwarfarins were developed following the emergence of warfarin resistance in rodents. Superwarfarins have much longer half-lives and stronger affinity to vitamin K epoxide reductase versus warfarin, and therefore can cause death in warfarin-resistant rodents. By the mid-1970s, the superwarfarins brodifacoum (BDF) and difenacoum (DiF) were the most widely used rodenticides throughout the world. Unfortunately, increased use was accompanied by a rise in accidental poisonings, reaching >16,000 per year in the United States. Risk of exposure has become a concern since large quantities, up to hundreds of kilograms of rodent bait, are applied by aerial dispersion over regions with rodent infestations. Reports of intentional use of superwarfarins in civilian and military scenarios raises the specter of larger incidents or mass casualties. Unlike warfarin overdose, for which 1–2 days of treatment with vitamin K is effective, treatment of superwarfarin poisoning with vitamin K is limited by extremely high cost and can require daily treatment for a year or longer. Furthermore, superwarfarins have actions that are independent of their anticoagulant effects, including both vitamin K–dependent and –independent effects, which are not mitigated by vitamin K therapy. In this review, we will summarize superwarfarin development, biology and pathophysiology, their threat as weapons, and possible therapeutic approaches.

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Residue profiles of brodifacoum in coastal marine species following an island rodent eradication

Cited by 37 publications

References 20 publications

Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences

Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences

A review: poisoning by anticoagulant rodenticides in non-target animals globally

The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures

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