Residue Study of Ivermectin in Plasma, Milk, and Mozzarella Cheese Following Subcutaneous Administration to Buffalo (<i>Bubalus bubalis</i>)

Anastasio, Aniello; Esposito, Mauro; Amorena, Michele; Catellani, P.; Serpe, Luigi; Cortesi, Maria Luisa

doi:10.1021/jf020181j

Cited by 33 publications

(27 citation statements)

References 15 publications

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“…Additionally, systemic insecticides from treated hosts becomes incorporated into dairy and meat products (65). Regulations have been established for levels of acceptable residues of a few drugs, such as eprinomectin; yet, most other drugs have not been licensed for use in dairy animals and thus do not have an acceptable limit for drug concentration found in milk (66).…”

Section: Discussionmentioning

confidence: 99%

Optimizing systemic insecticide use to improve malaria control

Meredith

Furuya‐Kanamori

Yakob

2019

Preprint

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9Long lasting insecticidal nets and indoor residual sprays have significantly reduced 10 the burden of malaria. However, several hurdles remain before elimination can be achieved: 11 mosquito vectors have developed resistance to public health insecticides, including 12 pyrethroids, and have altered their biting behaviour to avoid these indoor control tools. 13 Systemic insecticides, drugs applied directly to blood-hosts to kill mosquitoes that take a 14 blood meal, offer a promising vector control option. To date, most studies focus on 15 repurposing ivermectin, a drug used extensively to treat river blindness. There is concern that 16 over-dependence on a single drug will inevitably repeat past experiences with the rapid 17 spread of pyrethroid resistance in malaria vectors. Diversifying the arsenal of systemic 18 insecticides used for mass drug administration would improve this strategy's sustainability. 19Here, a review was conducted to identify systemic insecticide candidates and consolidate 20 their pharmacokinetic/pharmacodynamic properties. The impact of alternative integrated 21 vector control options and different dosing regimens on malaria transmission reduction are 22 illustrated through a mathematical model simulation. The review identified drugs from four 23 classes commonly used in livestock and companion animals: avermectics, milbemycins, 24 isoxazolines, and spinosyns. Simulations predicted that isoxazoline and spinosyn drugs were 25 promising candidates for mass drug administration, as they were predicted to need less 26 frequent application than avermectins and milbemycins to maintain mosquitocidal blood 27 concentrations. These findings will provide a guide for investigating and applying different 28 systemic insecticides to achieve better mosquito control strategies. 29 30 Significance: 32 The widespread use of long lasting insecticidal nets (LLINs) and indoor residual spray 33 has selected for mosquitoes that are resistant to pyrethroids or avoid exposure by feeding 34 outdoors or on livestock. Systemic insecticides, drugs that render a host's blood toxic to 35 feeding mosquitoes, could be an effective control strategy for mosquitoes with pyrethroid 36 resistance and/or outdoor feeding tendencies. Here, a number of existing systemic insecticide 37 candidates are identified and their pharmacokinetic properties in different drug-host-route 38 scenarios consolidated. These data were used to parameterise a mathematical model that 39 illustrated the projected gains achievable in malaria control programmes already employing 40 LLINs. The findings provide a guide for investigating and applying different systemic 41 insecticides to improve mosquito control strategies and reduce malaria transmission. 42 Introduction: 43 Long lasting insecticidal nets (LLINs) and indoor residual sprays (IRS) have played 44 significant roles in reducing the burden of malaria (1, 2). However, several hurdles remain 45 before elimination can be achieved. First, pyrethroids are heavily used in LLINs and, 46 previousl...

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Section: Discussionmentioning

confidence: 99%

Optimizing systemic insecticide use to improve malaria control

Meredith

Furuya‐Kanamori

Yakob

2019

Preprint

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“…However, a number of studies have been carried out into the depletion of ivermectin residues after administration to lactating cows [37,66], goats [67], sheep [68] and buffalo [69]. Alvinerie et al found that residue levels of ivermectin (sc 200 g/kg bw), reached a maximum concentration of 7.26 g/kg in goat milk at 2.8 days post-treatment and residues were detectable at >0.05 g/kg for 25 days post-treatment [67].…”

Section: Ivermectinmentioning

confidence: 99%

“…Cerkvenik et al found that residue levels of ivermectin (sc 200 g/kg bw) reached a maximum concentration of 23 g/kg in sheep milk at 1.3 days post-treatment and residues were detectable 23 for days after treatment [68]. Anastassio et al found that residue levels of ivermectin (sc 200 g/kg bw), reached a maximum concentration of 29 g/kg in buffalo milk at 2.5 days post-treatment and residues were detectable at 20 days post-treatment at a level of 0.6 g/kg [69]. Cerkvenik-Flajs et al investigated the fate of ivermectin residues in ewes' milk and dairy products (raw bulk milk, yoghurt from raw and pasteurised milk, cheese and whey) from ewes undergoing a residue depletion trial [70].…”

Section: Ivermectinmentioning

confidence: 99%

Review of methodology for the determination of macrocyclic lactone residues in biological matrices

Danaher

Howells

Crooks

et al. 2006

Journal of Chromatography B

125

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“…These factors fall into six general areas: (1) The pharmacology of the drug in animals, (2) The physiology of the udder, (3) The milk consumption, (4) The nutritional demands and pharmacology of the consumer, (5), The physical-chemical properties of the drug in the matrix, (6) The effect of the technological processes. Three of the most important biopharmaceutical factors that influence lactil drug excretion are protein binding, ion trapping and lipid solubility (Aniello et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Impact of Some Technological Factors on the Stability of Ciprofloxacin Residues in Milk

Elbehairy

2012

Journal of Food and Dairy Sciences

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The effect of the technological steps used in making and during the storage at 6°C for 15 days of concentrated yoghurt (Labneh) from reconstituted skim milk being spiked with veterinary residues, namely ciprofloxacin at concentration 100 ppm to study the behavior of this residues. In addition, the effect of the technological factors on residues stability during storage period was studied. Samples were analyzed for total solids, pH, organic acids namely formic, pyruvic, lactic and acetic acids and drug residues recovery at time intervals after 3, 7, 10 and 15 days. The obtained results revealed that the presence of the ciprofloxacin residues had no effect on the chemical parameters of concentrated yoghurt (Labenh) namely total solids, pH and the recoveries of organic acids. On the other hand, data indicated that this drug showed high thermal stability by separation using HPLC under the conditions of this study. The recovery of ciprofloxacin residues after 15 days of storage period may indicate that the reaction between drug residues and protein is chemical reaction. Thus, the application of HACCP system in milk production and processing must be taken into consideration to insure a safe product for the consumer.

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Residue Study of Ivermectin in Plasma, Milk, and Mozzarella Cheese Following Subcutaneous Administration to Buffalo (Bubalus bubalis)

Cited by 33 publications

References 15 publications

Optimizing systemic insecticide use to improve malaria control

Optimizing systemic insecticide use to improve malaria control

Review of methodology for the determination of macrocyclic lactone residues in biological matrices

Impact of Some Technological Factors on the Stability of Ciprofloxacin Residues in Milk

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