Women entrepreneurship is an inherent part of management compositions that stakeholders employ extensively to decipher ecumenical challenges. Given the status, the question occurs what it takes to transform women into entrepreneurs, particularly in circular bio-economies, before exploiting the entrepreneurial opportunities available with circular bio-economies, the collective efforts needed in the women entrepreneurship sphere. Research in this course was conducted based on expert opinion using the total interpretive structural modelling (TISM) technique. It depicts the twelve elements along with their causal relationship in the digraph with bold and transitive links. The study reveals that the hierarchical structural framework (digraph) is divided into six layers and three components stand in the first position. They are pro-social behaviour, emotional attachment, quality family fabrications, whereas technology transfer is at the bottom of the model. Further, in MICMAC analysis, all the elements are classified into autonomous, dependent, driving and linkage headings. A proper enhancement of these variables can augment several functions of the stakeholders.