Resilience and Self-Control Impairment

Evaluating Risk Factors of Self-Harm and Effectiveness of Brief Psychological Intervention During Acute Presentation: Methodology of EXPAAND Project

“…Our first hypothesis is that there exists a range of diagnostic and transdiagnostic mechanisms driving SH in C&A, and some of these are not routinely assessed in C&A within the acute SH episodes. In addition to conventional well-established RF (such as borderline traits, substance use, trauma, and PTSD), we expect that ADHD [37], SCT [31], Dissociative Disorder [30] and Alexithymia [28,29], are also key drivers. We aim to capture these phenomena via validated psychometric tools and evaluate quantitatively their associations with SH in C&A.…”

“…This process will inform development of more effective treatments. More specifically, apart from examining conventional RFs for SH, EXPAAND will also evaluate the links of SH and severity with the symptoms of ADHD [37], SCT [31], dissociation [30] and alexithymia [28,29]. Phase 2 data will provide opportunities to explore these.…”

“…Septier and colleagues' systematic review and meta-analysis found a significant association between ADHD and suicidal ideations, suicidal plans, suicidal attempts, and completed suicide (pooled Odds Ratio=6.69; 95% CI, 3.24-17.393) [35]. Apart from ADHD being an important driver of SH, independent from other covariates, further studies indicate that treatments of ADHD reduce the subsequent risks of SH [36,37]. Liu and colleagues reported that ADHD medication lowered the odds of suicide attempts by 0.76 (95% CI, 0.58-1.00; P = .049) at population-level analysis, whilst the individual level of analysis showed a 0.69 reduction [36].…”