Purpose : This study investigated coronavirus disease-19 (COVID-19) related stress, resilience, and organizational commitment, and determined the factors influencing nurses’ organizational commitment at an infectious disease hospital of COVID-19.Methods : A cross-sectional descriptive survey was conducted with 138 nurses. Data analysis, including descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlations, and multiple regression analysis, were performed using SPSS 26.0 program.Results : Factors influencing organizational commitment included resilience (<i>β</i>=0.31, <i>p</i><.001), position (<i>β</i>=0.31, <i>p</i><.001), COVID-19 related stress (<i>β</i>=-0.26, <i>p</i><.001), and COVID-19 nursing period (<i>β</i>=-0.19, <i>p</i>=.012). These variables explained 29.6% of the organizational commitment.Conclusion : In order to enhance the organizational commitment of nurses in infectious disease hospitals of COVID-19, active program development and intervention are required at the organizational level to improve nurses’ resilience and relieve stress related to nursing infectious disease patients.