Background Over 60% of the population in sub-Saharan Africa lives in informal settlements (slums) with little or no resources. To be prepared to meet the needs of older people living in slums, it is necessary to know more about their quality of life (QoL). The objective of this review is to identify instruments, which can be used by researchers to assess the QoL of older adults living in African countries, especially those dwelling in slums.Methods A scoping review was performed using the databases Scopus, PubMed, and ISI Web of Science to retrieve studies published between January 2008 – February 2019. Studies were included if they reported generic QoL instruments, focused on adults with a mean age ≥50 and were conducted in African countries.Results In total, 22 studies were included using 14 unique instruments to measure QoL (WHOQOL, SWLS, WHOQOL-OLD, the WHOQOL-BREF, SF-36, SF-12, RAND 36, WHO-SAGE-INDEPTH, CASP-19, CASP-12, the EQ-5D+C, EQ-6D, CAF and the adapted AMS). Almost all instruments could be interviewer-administered and had the possibility for content modification to better suit the research setting. However, little is known about their psychometric properties (validity and reliability), time-investment and cultural sensitivity of the domains included in the instruments.Conclusions Even though this review retrieved instruments used to assess QoL of older adults in African countries, there is a need for further research on adjustment and validation of currently existing QoL instruments. In addition, the development and validation of a new instrument which can be used in (illiterate) older populations, living in slums in Africa should be considered.