Background
The long-term consequences of wasting among HIV-infected persons are not known.
Design
HIV-infected participants surviving â„2 years based on Kaplan Meier analysis after a clinical diagnosis or weight trajectory consistent with wasting and with available physical function assessment data (grip strength, gait speed, and quality of life [QoL]) were matched to HIV-infected and -uninfected men without wasting.
Methods
Matching criteria at the functional assessment included age, calendar year, and CD4 cell count and plasma HIV-1 RNA (HIV-infected only). Multivariable linear regression analyses adjusted for age, cohort, race, hepatitis C status, and number of comorbid illnesses were used to assess the impact of wasting on subsequent physical function.
Results
Among 85 HIV-infected men surviving â„2 years after wasting, we evaluated physical function outcomes compared to 249 HIV-infected and 338 HIV-uninfected men with no historical wasting. In multivariable regression models, HIV-infected men with prior wasting had lower grip strength and poorer physical QoL than HIV-infected men with no wasting (pâ€0.03), and poorer physical QoL but higher mental QoL than HIV-uninfected men (pâ€0.05). When controlling for measures of immune suppression (nadir CD4/AIDS, the association between wasting and physical QoL was markedly attenuated, whereas there was minimal impact on the association between wasting and grip strength.
Conclusions
HIV-infected wasting survivors had weaker grip strength compared to HIV-infected persons without wasting; immune suppression was associated only with physical QoL. HIV-infected survivors of wasting may represent a population of adults at increased risk for physical function decline.