The chronic nature of severe mental illnesses is necessary for constant care provided by the family caregivers. Considering the significance of family caregivers in providing care, it is imperative to ensure their self-care if they are to play the role of caregiving effectively and efficiently well. The present study was conducted using the purposive sampling method and in-depth semi-structured interviews among 13 family caregivers and five health team members. The data were analyzed via a conventional content analysis approach. In the data analysis, seven main categories and 18 subcategories emerged: “A troublesome patient and me,” including “Care-induced distress,” “Caring dilemma,” “Emotional fluctuations,” and “Self-forgetfulness”; “Passive–destructive individuality,” including: “Mental stereotypes” and “Unhealthy lifestyle”; “Family turbulence,” including: “Family malfunction” and “Break in family ties”; “The conjoined influencing social factor,” including “Lack of awareness at the family and community level” and “Social stigmatization”; “lack of well-organized health care system,” including “Biomedical-oriented health system,” “Disruption in continuity of care,” and “Problems associated with the support provided by the health system”; “Disturbed economic conditions,” including “Difficulty in life with disrupted financial capability,” “Problems related to education and promoting awareness,” and “Family health care problems”; “Dysfunctional Public mental health,” including “Macro-dysfunction of mental health education,” and “Disruptive advocacy activities to support families of patients with mental disorders.” There are several barriers to family caregiver self-care planning that require health professionals to develop appropriate interventions.