ObjectivesThe study aimed to evaluate the debonding resistance of three different endocrown designs on molar teeth, using three different zirconia surface pretreatments.Material and MethodNinety human mandibular first molars were divided into three main groups: endocrowns without ferrule, with 1 mm ferrule, and with 2 mm ferrule. The subgroups were defined by their surface pretreatment method used (n = 15): 50 μm alumina air‐particle abrasion, silica coating using 30 μm Cojet™ particles, and Zircos‐E® etching. The endocrowns were fabricated using multilayer zirconia ceramic, cemented with self‐adhesive resin cement, and subjected to 5000 thermocycles (5–55°C) before debonding. The data obtained were analyzed using a two‐way ANOVA.ResultsAll test specimens survived the thermocyclic aging. The results indicated that both the preparation design and the surface treatment had a significant impact on the resistance to debonding of the endocrowns (p < .001). The 2 mm ferrule followed by the 1 mm ferrule designs exhibited the highest debonding resistance, both were superior to the endocrown without ferrule. Zircos‐E® etching and silica coating yielded comparable debonding resistance, which were significantly higher than alumina air‐particle abrasion. All endocrowns demonstrated a favorable failure mode.ConclusionsAll designs and surface treatments showed high debonding resistance for a single restoration. However, ferrule designs with Zircos‐E® etching or silica coating may represent better clinical options compared to the nonferrule design or alumina airborne‐particle abrasion. Nonetheless, further research, including fatigue testing and evaluations with different luting agents is recommended.