Resin glycosides from the leaves and stems of Ipomoea digitata

Ono, M.; Fukuda, Hitoshi; Murata, Hiroko; Miyahara, Kazumoto

doi:10.1007/s11418-008-0309-1

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…In Ayurveda it is used as a general tonic. The leaves contain organic acids, isobutyric, (S)-2-methylbutyric, tiglic, n-decanoic, n-dodecanoic, cinnamic acids, and glycosidic acids, quamoclinic acid A and operculinic acid A [186]. …”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Aggarwal¹,

Prasad²,

Reuter

et al. 2011

CDT

363

155

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Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed these observations and identified the molecular basis for most chronic diseases and for the associated inflammation. The transcription factor, Nuclear Factor-kappaB (NF-κB) that controls over 500 different gene products, has emerged as major mediator of inflammation. Thus agents that can inhibit NF-κB and diminish chronic inflammation have potential to prevent or delay the onset of the chronic diseases and further even treat them. In an attempt to identify novel anti-inflammatory agents which are safe and effective, in contrast to high throughput screen, we have turned to “reverse pharmacology” or “bed to benchside” approach. We found that Ayurveda, a science of long life, almost 6000 years old, can serve as a “goldmine” for novel anti-inflammatory agents used for centuries to treat chronic diseases. The current review is an attempt to provide description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit.

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Section: Introductionmentioning

confidence: 99%

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Aggarwal¹,

Prasad²,

Reuter

et al. 2011

CDT

363

155

View full text Add to dashboard Cite

show abstract

“…This mixture was saponified and the products were methylated with diazomethane ether. Subsequent HPLC separation gave two methyl esters (12,13) of glycosidic acids. On alkaline hydrolysis, 8-13 gave free glycosidic acids, 8a-13a, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…All instruments and materials used were as cited in the preceding report [2,12,13], unless otherwise specified.…”

Section: Generalmentioning

confidence: 99%

Components of convolvulin from Quamoclit × multifida

et al. 2010

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Alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction of the seeds of Quamoclit × multifida (syn. Q. sloteri House, Convolvulaceae), a hybrid between Q. pennat and Q. coccinea, gave three new glycosidic acids (maltifidinic acids C, D, and E) along with three known glycosidic acids (quamoclinic acids B, C, and D) and four organic acids (2S-methylbutyric, tiglic, 2R,3R-nilic, and 7S-hydroxydecanoic acids). The structures of the new glycosidic acids were characterized on the basis of spectroscopic data as well as chemical evidence.

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“…The instruments and materials used were as cited in the preceding report 17,18) unless otherwise specified. Isolation of 1a and 2a Fraction 14 (95 mg) and fraction 19 (111 mg), which were obtained previously 11) from the glycosidic acid fraction treated with phenacylbromide in dimethylformamide, were combined, and subjected to HPLC [column, (Inertsil octadecyl silica (ODS), 6 mm i.d.ϫ25 cm)ϩ (Cosmosil 5C18-Ar, 6 mm i.d.ϫ25 cm); solvent, 70% MeOH] to yield 1a (67 mg) and 2a (47 mg).…”

Section: Methodsmentioning

confidence: 99%

Two New Glycosidic Acids, Quamoclinic Acids G and H, of the Resin Glycosides (Convolvulin) from the Seeds of Quamoclit pennata

2010

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Two new glycosidic acids, quamoclinic acids G and H, were isolated from the glycosidic acid fraction afforded by alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction from the seeds of Quamoclit pennata BOJER. Both compounds are the first examples of bisdesmosides of glycosidic acid having the sugar linkages at C-3 of 3,11-dihydroxytetradecanoic acid (ipurolic acid) as well as at its C-11.

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Resin glycosides from the leaves and stems of Ipomoea digitata

Cited by 9 publications

References 10 publications

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Components of convolvulin from Quamoclit × multifida

Two New Glycosidic Acids, Quamoclinic Acids G and H, of the Resin Glycosides (Convolvulin) from the Seeds of Quamoclit pennata

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Resin glycosides from the leaves and stems of Ipomoea digitata

Cited by 9 publications

References 10 publications

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: &#x201C;Reverse Pharmacology&#x201D; and &#x201C;Bedside to Bench&#x201D; Approach

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: &#x201C;Reverse Pharmacology&#x201D; and &#x201C;Bedside to Bench&#x201D; Approach

Components of convolvulin from Quamoclit × multifida

Two New Glycosidic Acids, Quamoclinic Acids G and H, of the Resin Glycosides (Convolvulin) from the Seeds of Quamoclit pennata

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Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach

Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach