The aim of this study was to evaluate the potential of coloring of two commercial beverages: coffee and wine, and cigarette smoke, on three materials (ICON infiltration resin, MI Varnish Recaldent, and a sealant based on composite resin) currently used in incipient caries therapy. The study group included 75 extracted teeth that were divided into 3 groups corresponding to each material used. The groups were divided into 5 subgroups that corresponded to each colorant (A. red wine, B. coffee, C. cigarette smoke, D. association of the three colorants, E. control group). The coloration degree of the samples was measured both after the moment of coloring (M3) and after polishing (M4). The results showed a significant increase of the coloring degree for the samples subjected to the combined action of the three colorants (M3), for all the three materials used (DE1*: Id = 23.56, IId = 25.87, IIId = 19.87), and in terms of the coloring degree after the polishing procedure (M4), a decrease of the values was observed (DE2*: Id = 17.56, IId = 21.67, IIId = 16.78). In conclusion, both exposure to the two beverages used in the study and cigarette smoke (C) leads to the appearance of color changes, but the most significant changes were obtained by combining the three colorants (D). Also, the polishing procedure leaded to an improvement of the color variation for all three materials.