Resin Infiltration of Caries in Primary Molars in a Community Setting: 24-Month Randomized Controlled Trial Findings

Page, Lyndie A. Foster; Beckett, Deanna; Ahmadi, Rulam; Schwass, Donald R.; Barra, Sophia Leon de la; Moffat, Susan M.; Meldrum, Alison; Thomson, W. Murray

doi:10.1177/2380084417699400

Cited by 14 publications

(19 citation statements)

References 23 publications

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“…They reported adequate concealment measures for random allocation of intervention and control/placebo to NCPLs. Such measures were placing the random sequence inside sealed envelopes[171819] and letter coding of each NCPL management strategy,[20] whereas the remaining three studies did not report any means of allocation concealment and therefore were judged to have an unclear risk of bias. However, they were not excluded because this was not likely to affect the outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies reported all the prespecified outcomes and therefore were judged to have a low risk of bias. [1718192223] In contrast, two trials were at high risk of bias since they failed to mention all their prespecified outcomes. Ekstrand et al [20] did not report the results of their 6-month clinical assessment, and the radiographic evaluation was incomplete.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of resin infiltrate in noncavitated proximal carious lesions: A systematic review and meta-analysis

Elrashid¹,

Alshaiji²,

Saleh³

et al. 2019

J Int Soc Prevent Communit Dent

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Objectives: Resin infiltration is a minimally invasive technique for treating noncavitated proximal caries. It slows/stops the carious lesion progression rate by creating a diffusion barrier inside the porous enamel lesion body. The aim was to evaluate the efficacy of resin infiltration on noncavitated proximal carious lesions in primary and permanent teeth. Materials and Methods: The records were obtained using electronic and other sources. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed to ensure transparent reporting. Eligible studies were randomized controlled trials evaluating the efficacy of resin infiltration for noncavitated proximal carious lesions by comparing it with control/placebo. Each included study was assessed concerning the “risk of bias” using the Cochrane Collaboration's “risk-of-bias” assessment tool. High risk-of-bias studies were excluded from the meta-analyses due to selective reporting matters. The statistics were performed by RevMan software (The Cochrane Collaboration, The Nordic Cochrane Centre, Copenhagen, Denmark) utilizing the random effect model. The GRADE approach was implemented for assessing the quality of evidence. Results: From 106 studies identified, 17 were assessed for eligibility. After “risk-of-bias” assessment, two meta-analyses were conducted to eliminate the limitation of the significant heterogeneity between trials inspecting primary teeth ( n = 2) and permanent teeth ( n = 3). I 2 = 0% indicates the absence of statistical heterogeneity. The risk of carious lesions’ progression with resin infiltration was significantly lower in primary (risk ratio [RR]; 95% confidence interval [CI]: 0.48; 0.30–0.75, P = 0.001) and in permanent teeth (RR; 95% CI: 0.19; 0.11–0.33, P < 0.00001) compared to that of control/placebo. The GRADE approach revealed high quality of evidence. Conclusion: The available evidence conveys high confidence that proximal resin infiltration has superior efficacy in slowing/arresting the carious lesions’ progression rate in comparison to conventional management modalities.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy of resin infiltrate in noncavitated proximal carious lesions: A systematic review and meta-analysis

Elrashid¹,

Alshaiji²,

Saleh³

et al. 2019

J Int Soc Prevent Communit Dent

View full text Add to dashboard Cite

show abstract

“…The remaining five studies assessed lesions in primary teeth (261 patients, 522 lesions) [ 63 , 64 , 65 , 66 , 67 ]. Follow-up ranged between 12 to 24 months (median: 24 months) with a yearly drop-out of 2–11% (median: 10%).…”

Section: Resultsmentioning

confidence: 99%

Resin Infiltration of Non-Cavitated Proximal Caries Lesions in Primary and Permanent Teeth: A Systematic Review and Scenario Analysis of Randomized Controlled Trials

Cebula

Göstemeyer

Krois

et al. 2023

JCM

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The present study aimed to meta-analyze and evaluate the certainty of evidence for resin infiltration of proximal carious lesions in primary and permanent teeth. While resin infiltration has been shown efficacious for caries management, the certainty of evidence remains unclear. The protocol was registered with PROSPERO (CRD42018080895), and PRISMA guidelines have been followed. The databases PubMed, Embase, and Cochrane CENTRAL were systematically screened, complemented by hand searches and cross-referencing. Eleven relevant articles were identified and included, i.e., randomized controlled trials (RCTs) comparing the progression of resin infiltrated proximal caries lesions (combined with non-invasive measures) in primary or permanent teeth with non-invasive measures. Random-effects meta-analyses and trial sequential analyses (TSA) were performed for per-protocol (PP), intention-to-treat (ITT), and best/worst case (BC/WC) scenarios. Six included trials assessed lesions in permanent teeth and five trails assessed lesions in primary teeth. The trials had a high or unclear risk of bias. Risk of caries progression was significantly reduced for infiltrated lesions in the PP, ITT, and BC scenarios in both permanent teeth and primary teeth, but not in the WC scenario. According to the TSA, firm evidence was reached for all of the scenarios except the WC. In conclusion, there is firm evidence for resin infiltration arresting proximal caries lesions in permanent and primary teeth.

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“…A meta-analysis by Chen et al in 2021 concluded that although more clinical studies were needed, findings from current studies were encouraging and resin infiltration is efficacious in arresting decay progress in primary teeth for 12–24 months [ 130 ]. Based on these studies, the therapeutic effect of RI was found to range from 21% [ 134 , 135 ] to 38% [ 136 ].…”

Section: Resin Infiltration For the Management Of Carious Lesionsmentioning

confidence: 99%

Minimally Invasive Therapies for the Management of Dental Caries—A Literature Review

2021

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In recent years, due to a better understanding of the caries pathology and advances in dental materials, the utilization of non-invasive and minimally invasive techniques that delay/obviate the need for traditional restorations has started gaining momentum. This literature review focuses on some of these approaches, including fluoride varnish, silver diamine fluoride, resin sealants, resin infiltration, chemomechanical caries removal and atraumatic restorative treatment, in the context of their chemistries, indications for use, clinical efficacy, factors determining efficacy and limitations. Additionally, we discuss strategies currently being explored to enhance the antimicrobial properties of these treatment modalities to expand the scope of their application.

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Resin Infiltration of Caries in Primary Molars in a Community Setting: 24-Month Randomized Controlled Trial Findings

Abstract: These study findings can help clinicians decide which caries management approach they wish to use to prevent progression of proximal lesions in primary molars. With consideration of cost and patient preference, this information could lead to more appropriate therapeutic decisions.

Cited by 14 publications

References 23 publications

Efficacy of resin infiltrate in noncavitated proximal carious lesions: A systematic review and meta-analysis

Efficacy of resin infiltrate in noncavitated proximal carious lesions: A systematic review and meta-analysis

Resin Infiltration of Non-Cavitated Proximal Caries Lesions in Primary and Permanent Teeth: A Systematic Review and Scenario Analysis of Randomized Controlled Trials

Minimally Invasive Therapies for the Management of Dental Caries—A Literature Review

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