Resistance exercise shifts the balance of renin-angiotensin system toward ACE2/Ang 1–7 axis and reduces inflammation in the kidney of diabetic rats

Santos, Ralmony de Alcântara; Guzzoni, Vinícius; Silva, Kleiton Augusto Santos; Aragão, Danielle Sanches; Vieira, Rodolfo de Paula; Bertoncello, Nádia; Schor, Nestor; Aimbire, Flávio; Casarini, Dulce Elena; Cunha, Tatiana Sousa

doi:10.1016/j.lfs.2021.120058

Cited by 15 publications

(6 citation statements)

References 55 publications

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“…Decreased ACE activity and increased ACE2 activity were observed in the kidneys of the DN rats undergoing resistance training, leading to decreased levels of inflammatory cytokines. Resistance exercise reduced the levels of Ang I and Ang II and increased the concentration of Ang-(1-7) in the kidneys [61]. Ang II can promote kidney inflammation in DN rats, while Ang-(1-7) can counteract the effect of Ang II on promoting kidney inflammation.…”

Section: Role Of Exercise-regulated Renin-angiotensin System In Ameli...mentioning

confidence: 88%

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism

Li,

Guo

2024

IJMS

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Diabetic nephropathy (DN) is a serious complication of diabetes, and its progression is influenced by factors like oxidative stress, inflammation, cell death, and fibrosis. Compared to drug treatment, exercise offers a cost-effective and low-risk approach to slowing down DN progression. Through multiple ways and mechanisms, exercise helps to control blood sugar and blood pressure and reduce serum creatinine and albuminuria, thereby alleviating kidney damage. This review explores the beneficial effects of exercise on DN improvement and highlights its potential mechanisms for ameliorating DN. In-depth understanding of the role and mechanism of exercise in improving DN would pave the way for formulating safe and effective exercise programs for the treatment and prevention of DN.

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Section: Role Of Exercise-regulated Renin-angiotensin System In Ameli...mentioning

confidence: 88%

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism

Li,

Guo

2024

IJMS

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“…7 C. Continued interest in Islet cell function (cluster#4) and insulin resistance (cluster#7), pivotal pathogenic mechanisms in diabetic microvascular complications, has been well documented. It has been shown that activation of the ACE2/Ang 1–7 axis enhances glucose metabolism and ameliorates insulin resistance [ [49] , [50] , [51] ]. Compared to wild type mice, ACE2-knockout mice exhibit greater vulnerability to pancreatic β-cell dysfunction induced by high-fat diets [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…In vitro studies show human recombinant ACE2 enhances Ang 1–7 signaling, reducing angiotensin II levels [ 60 ]. Resistance training alters the renal renin-angiotensin system in diabetes, reducing inflammatory markers such as interleukins and cytokine-induced neutrophil chemoattractant-1 [ 51 ]. Olmesartan treatment in type 2 diabetes patients decreased urinary albumin excretion, linked to increased serum Ang 1–7 and ACE2 levels, suggesting their therapeutic potential in diabetic nephropathy [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and visual analysis of ACE2/Ang 1–7/MasR axis in diabetes and its microvascular complications from 2000 to 2023

Hu,

Tan,

Lin

et al. 2024

Heliyon

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“…This is interesting because the situation was different in the case of the concentrations of this enzyme-patients from the control group had higher concentrations of this parameter. Low ACE activity in patients with diabetic nephropathy may result from compensatory adaptation aimed at reducing the production of additional angiotensin II (Ang II) [30,31].…”

Section: Discussionmentioning

confidence: 99%

The Role of Angiotensin-Converting Enzyme (ACE) Polymorphisms in the Risk of Development and Treatment of Diabetic Nephropathy

Król-Kulikowska,

Abramenko,

Jakubek

et al. 2024

JCM

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Background: Angiotensin-converting enzyme (ACE) is responsible for the production of angiotensin II, and increased production of angiotensin II is observed in diabetes. What is more, ACE polymorphisms may play a role in the development of diabetic nephropathy. The aim of this study was to assess the role of selected ACE polymorphisms (rs4343 and rs4646994) in the risk of development of diabetic nephropathy and in the likelihood of renal replacement therapy. Methods: ACE polymorphisms were analyzed in a group of 225 patients who were divided into three subgroups. The rs4343 polymorphism was determined using the PCR-RFLP, and the rs4646994 polymorphism was determined using the PCR. Molecular docking between domains of ACE and its ligands was performed by using AutoDock Vina. Results: The G/G genotype of rs4343 polymorphism is associated with increased odds of developing diabetic nephropathy. The G allele is also associated with a higher risk of this disease. Similar results were obtained in patients who had already had a kidney transplant as a result of diabetic nephropathy. Conclusions: The presence of G/G and G/A genotypes, and the G allele increases the likelihood of developing diabetic nephropathy. This may also be a risk factor for renal replacement therapy.

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Resistance exercise shifts the balance of renin-angiotensin system toward ACE2/Ang 1–7 axis and reduces inflammation in the kidney of diabetic rats

Cited by 15 publications

References 55 publications

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism

Bibliometric and visual analysis of ACE2/Ang 1–7/MasR axis in diabetes and its microvascular complications from 2000 to 2023

The Role of Angiotensin-Converting Enzyme (ACE) Polymorphisms in the Risk of Development and Treatment of Diabetic Nephropathy

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