Resistance exercise training increase activation of AKT-eNOS and Ref-1 expression by FOXO-1 activation in aorta of F344 rats

Abstract

. Resistance exercise training increase activation of AKT-eNOS and Ref-1 expression by FOXO-1 activation in aorta of F344 rats. JENB., Vol. 19, No. 3, pp.165-171, 2015 [Purpose] This study investigated the effects of resistance exercise on the Akt-eNOS, the activation of antioxidant protein and FOXO1 in the aorta of F344 rats.[Methods] Male 7 week-old F344 rats were randomly divided into 2 groups: a climbing group (n = 6) and a sedentary group (n = 6). H&E staining and western blotting were used to analyze the rat aortas and target proteins.

Resistance training improves aortic structure in Wistar rats

“…21 , 23 Our finding is not in agreement with the observation that there is no significant increase in aortic parameters after resistance training in rats. 25 This discrepancy may be mainly due to the different protocol used by these authors. The training was not adjusted according to the body weight of the animals, and there was no information on whether the training load was set at 60% of 1RM.…”