Resistance induced in rats by previous exposure to and by vaccination with fresh homogenates of Schistosoma mansoni

Sadun, E. H.; Bruce, J. I.

doi:10.1016/0014-4894(64)90005-0

Cited by 21 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experiment 1 showed that on the whole recovery was low in both strains. This is in conformity with previous reports on work with other strains (Stirewalt et al, 1951 ;Sadun and Bruce, 1964 ;Warren and Peters, 1967).…”

Section: Discussionsupporting

confidence: 94%

The Susceptibility of London-hooded and Wistar rats of Experimental Infection with Schistosoma mansoni

1971

J. Helminthol.

View full text Add to dashboard Cite

1. The susceptibility of two strains of rats, namely London-hooded and Wistar, to infection with S. mansoni has been investigated2. Although equal numbers of cercariae penetrated the skin in both strains, recovery of worms was always higher from the London-hooded strain irrespective of the dosage level.3. In both strains there was a significant relationship between body weight at time of infection and number of worms recovered. The correlation was a negative one, indicating that lighter (younger) rats were more susceptible than heavier (older) rats.4. A rapid rate of elimination of infection was demonstrated in London-hooded rats between the 4th and 8th week after infection.

show abstract

Section: Discussionsupporting

confidence: 94%

The Susceptibility of London-hooded and Wistar rats of Experimental Infection with Schistosoma mansoni

1971

J. Helminthol.

View full text Add to dashboard Cite

show abstract

“…In our study, the prepatent period was significantly higher in sheep and goats than in calves and worm recoveries were higher from calves and goats than from sheep. No infection resulted from the exposure of a buffalo calf and our epidemiological data on 69 buffaloes slaughtered from -1970and 65 buffaloes slaughtered from 1962-1964(Arfaa et al, 1965 in Khuzestan suggests that this animal is naturally resistant to S. bovis infection. Faust (1924) noted that the water buffalo wades in areas infected with the cercariae of S.japonicum without developing the infection, and he suggested that the thick skin of these animals might explain their apparent immunity, but Fairley et al (1930) showed that buffaloes can be infected percutaneously with the cercariae of S. spindale.…”

Section: Plate IImentioning

confidence: 70%

Parasitological and Pathological Observations on Schistosoma bovis Sonsion, 1876, in Calves, Sheep and Goats in Iran

Massoud

1973

J. Helminthol.

View full text Add to dashboard Cite

Seven calves, 5 sheep, 2 goats and one buffalo calf were exposed to S. bovis cercariae in the laboratory. The prepatent period varied from 44–45 days in calves, 47–50 days in sheep to 47–48 days in goats. The recovery rate of adult worms was 62.1% in calves, 41.4% in sheep and 67.3% in goats. The infection rates were much higher than those obtained by previous workers, possibly because of a superior technique. One buffalo calf was exposed to S. bovis cercariae but showed no signs of infection.The mean daily egg output per gram of faeces was 75 in calves, 60 in sheep and 75 in goats. The daily egg output in the faeces per individual female worm was 106 in calves, 52 in sheep and 48 in goats at 9 weeks after exposure to cercariae. The number of eggs passed in the faeces decreased in calves and increased in sheep as the duration of infection was prolonged.

show abstract

“…The host-parasite relationships of Schistosoma mansoni in the albino rat have been studied recently by Ritchie, Garson & Knight (1963) and by Sadun & Bruce (1964). The general findings of these and other workers are that, in rats, the worms are always stunted, although they may pair and non-viable eggs may be found in the liver.…”

Section: Introductionmentioning

confidence: 96%

Acquired resistance to experimental infections of Schistosoma mansoni in the albino rat

Smithers

Terry

1965

Parasitology

View full text Add to dashboard Cite

The host–parasite relationships of Schistosoma mansoni in the albino rat have been studied recently by Ritchie, Garson & Knight (1963) and by Sadun & Bruce (1964). The general findings of these and other workers are that, in rats, the worms are always stunted, although they may pair and non-viable eggs may be found in the liver. The worms remain in the liver and seldom, if ever, migrate to the mesenteries. Ritchie et al. (1963) found that the majority of the worms were eliminated between the 4th and 8th week after infection; this is much sooner than in other experimental hosts. Sadun & Bruce (1964) suggest that rats are particularly suitable and convenient for studies on acquired resistance to S. mansoni; this suggestion is based mainly on the grounds that acquired resistance is more easily demonstrated in animals which show a relatively great degree of innate resistance.The present work has been undertaken in order to establish whether the immune response in the albino rat is at all similar to that in the rhesus monkey (Smithers & Terry, 1965b). Two features of the host–parasite system have been studied in detail; the elimination of the worms which follows an initial infection and a comparison of the development of acquired resistance following exposure to X-irradiated cercariae with that following exposure to normal cercariae.A Puerto-Rican strain of S. mansoni, and Sprague–Dawley rats weighing 100–200 g, were used in all experiments. The methods of exposing the rats percutaneously to infection and the recovery of the worms by perfusion have been fully described (Smithers & Terry, 1965 a).

show abstract

Resistance induced in rats by previous exposure to and by vaccination with fresh homogenates of Schistosoma mansoni

Cited by 21 publications

References 31 publications

The Susceptibility of London-hooded and Wistar rats of Experimental Infection with Schistosoma mansoni

The Susceptibility of London-hooded and Wistar rats of Experimental Infection with Schistosoma mansoni

Parasitological and Pathological Observations on Schistosoma bovis Sonsion, 1876, in Calves, Sheep and Goats in Iran

Acquired resistance to experimental infections of Schistosoma mansoni in the albino rat

Contact Info

Product

Resources

About