Resistance mechanism of Phomopsis longicolla to fludioxonil is associated with modifications in PlOS1, PlOS4 and PlOS5

Wei, Lingling; Chen, Bin; Li, Jiawei; Zhang, Pengcheng; Chen, Wenchan; Ye, Wenwu; Chen, Changjun

doi:10.1016/j.pestbp.2024.105862

Pesticide Biochemistry and Physiology

2024

DOI: 10.1016/j.pestbp.2024.105862

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Resistance mechanism of Phomopsis longicolla to fludioxonil is associated with modifications in PlOS1, PlOS4 and PlOS5

Lingling Wei,

Bin Chen,

Jiawei Li

et al.

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2024

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Cited by 2 publications

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A new canker on Camellia sinensis (L.) Kuntze associated with Diaporthe longicolla and Lasiodiplodia theobromae in India

Pandey,

Sharma,

Yadav

et al. 2024

Physiological and Molecular Plant Pathology

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A new canker on Camellia sinensis (L.) Kuntze associated with Diaporthe longicolla and Lasiodiplodia theobromae in India

Pandey,

Sharma,

Yadav

et al. 2024

Physiological and Molecular Plant Pathology

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A Novel Point Mutation M460I in Histidine Kinase FgOs1 Confers High Resistance to Fludioxonil in Fusarium graminearum

Wang,

Li,

Cong

et al. 2024

J. Agric. Food Chem.

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Fusarium head blight (FHB), caused by Fusarium graminearum, severely impacts global wheat production, reducing both the yield and quality. In China, fludioxonil, a phenylpyrrole fungicide, is used for managing FHB. This study assessed fludioxonil activity against 120 F. graminearum strains collected from Hubei, Zhejiang, and Jiangsu in 2024, revealing an average EC 50 value of 0.0273 ± 0.0062 μg/mL. We obtained two resistant mutants through chemical taming and discovered a novel point mutation of FgOs1-M460I. Site-directed mutagenesis confirmed that the FgOs1-M460I mutation greatly reduced fludioxonil sensitivity, with an EC 50 value greater than 100 μg/mL. These mutants also displayed reduced sexual and asexual reproduction and lower virulence and accumulated less glycerol under fludioxonil and osmotic stress compared to sensitive strain. The resistant mutants showed no cross-resistance with carbendazim, tebuconazole, phenamacril, pyraclostrobin, or pydiflumetofen. Thus, we conclude that the FgOs1-M460I substitution regulates fludioxonil resistance and plays a role in asexual reproduction, sexual reproduction, and pathogenicity.

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Resistance mechanism of Phomopsis longicolla to fludioxonil is associated with modifications in PlOS1, PlOS4 and PlOS5

Cited by 2 publications

References 54 publications

A new canker on Camellia sinensis (L.) Kuntze associated with Diaporthe longicolla and Lasiodiplodia theobromae in India

A new canker on Camellia sinensis (L.) Kuntze associated with Diaporthe longicolla and Lasiodiplodia theobromae in India

A Novel Point Mutation M460I in Histidine Kinase FgOs1 Confers High Resistance to Fludioxonil in Fusarium graminearum

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