Resistance mechanisms of mucoid-grownStaphylococcus aureusto the antibacterial action of some disinfectants and antiseptics

Abstract

The effects of commercial preparations of some disinfectants and antiseptics on mucoid‐grown Staphylococcus aureus were investigated. Substantial reductions in their killing efficiencies were observed in the presence of mucoid‐grown staphylococci but not with non‐mucoid organisms. The reductions in antibacterial efficacies were comparable to the inhibitory effects of hard water, killed yeast, asparagine, blood plasma, thioglycollate and Tween‐80. These reductions could be eliminated by washing mucoid organisms in saline broth or sub‐culturing in BHI broth. This indicated that protection by the extracellular slime covering is an effective resistance mechanism of mucoid‐grown staphylococci.

Bacteria on Meat Abattoir Process Surfaces after Sanitation: Characterisation of Survival Properties of <i>Listeria monocytogenes</i> and the Commensal Bacterial Flora

“…Staphylococcus sp. may harbour plasmid encoding for efflux pumps for QAC, which lead to increased tolerance [40,41] and resistance to several biocides has been linked to mucoid growth [42]. Serratia was found to be resistant to the disinfectant containing QAC.…”

Quaternary Ammonium Salts and Their Antimicrobial Potential: Targets or Nonspecific Interactions?

“…The Gramnegative bacterium Pseudomonas aeruginosa and bacteria that are embedded in biofilm matrices are less susceptible to QACs and other antiseptics. [39,40] These observations indicate a crucial role played by particular surface structures of various bacterial species in sensitivity to QACs. Likewise, mycobacteria, which have a unique cell wall consisting of a hydrophobic mycolate layer and a peptidoglycan layer linked by the polysaccharide arabinogalactan, show high resistance to QACs.…”