Resistance of bacterial biofilms to disinfectants: a review

Bridier, Arnaud; Briandet, Romain; Thomas, Vincent; Dubois‐Brissonnet, Florence

doi:10.1080/08927014.2011.626899

Cited by 741 publications

(559 citation statements)

References 192 publications

(173 reference statements)

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“…An immediate application of swimmer-induced channels is to facilitate access to currently used surface disinfectants, such as oxidizing agents or quaternary ammonium compounds. Compared with planktonic cells, bacteria embedded in biofilms are typically 10-to 1,000-fold more resistant to these products (4,26). Improved biocide efficacy against staphylococci in the presence of bacilli opens the door to novel treatment strategies that make use of lower amounts of environmentally polluting disinfectants.…”

Section: Discussionmentioning

confidence: 99%

Bacterial swimmers that infiltrate and take over the biofilm matrix

Houry

Gohar

Deschamps

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

186

149

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Bacteria grow in either planktonic form or as biofilms, which are attached to either inert or biological surfaces. Both growth forms are highly relevant states in nature and of paramount scientific focus. However, interchanges between bacteria in these two states have been little explored. We discovered that a subpopulation of planktonic bacilli is propelled by flagella to tunnel deep within a biofilm structure. Swimmers create transient pores that increase macromolecular transfer within the biofilm. Irrigation of the biofilm by swimmer bacteria may improve biofilm bacterial fitness by increasing nutrient flow in the matrix. However, we show that the opposite may also occur (i.e., swimmers can exacerbate killing of biofilm bacteria by facilitating penetration of toxic substances from the environment). We combined these observations with the fact that numerous bacteria produce antimicrobial substances in nature. We hypothesized and proved that motile bacilli expressing a bactericide can also kill a heterologous biofilm population, Staphylococcus aureus in this case, and then occupy the newly created space. These findings identify microbial motility as a determinant of the biofilm landscape and add motility to the complement of traits contributing to rapid alterations in biofilm populations.bacterial ecology | biofilm disruption | motile subpopulations | antimicrobials | time-lapse confocal imaging

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Section: Discussionmentioning

confidence: 99%

Bacterial swimmers that infiltrate and take over the biofilm matrix

Houry

Gohar

Deschamps

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

186

149

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“…Although biocide treatment eliminates most surface contamination some microorganisms may survive and give rise to public health problem [5]. The wide spread use of antiseptic result in cross resistance to antibiotic [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chlorhexidine and Sodium Hypochlorite on Staphylococcus aureus Biofilm

Abdallah¹,

Abakar²

2017

J Prev Infect Cntrol

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Biofilm is a matrix in which a microorganism encases in it and survives environmental stresses. It help the organisms to resist the antibiotics and disinfectant, chronic biofilm associated infection lead to significant increase in morbidity and mortality especially patient with indwelling medical devices. The objective of this research was to analyze the effectiveness of chlorhexidine, sodium hypochlorite and antimicrobial activity of methicillin and vancomycin against biofilm of isolated strains of Staphylococcus aureus isolated from different clinical samples. The results revealed that most biofilm strains were sensitive to vancomycin, some strains were sensitive some were moderate resist and some were resist to methicillin. In comparing different concentrations (0.3%, 0.2%, 0.15% and 0.075%) of chlorhexidine among time interval (1 min, 3 min and 5 min) concentrations showed significant decrease in biofilm formation in association with time; P value (0.001, 0.001, 0.000 and 0.000, respectively). Different concentrations (5%, 4%, 2.5% and 1.25%) of sodium hypochlorite also tested through the same time intervals; concentrations showed significant decrease in biofilm in association with time; P value (0.000, 0.000, 0.000 and 0.000, respectively).

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“…Sonuç olarak, direnç plazmidlerinin aktarılması sayesinde genetik yapısı değişen hücreler antimikrobiyal ajanlara karşı daha fazla direnç kazanmış olur. 13,14 Cerrahiz periodontal tedaviye ek olarak antibiyotik kullanımı nasıl gündeme gelmiştir? Cerrahisiz periodontal tedavinin, periodontal anatomiye, hastaya ve hekime bağlı çeşitli sınırlamaları vardır.…”

Section: Discussionunclassified

When and How to use Antibiotics in Periodontal Treatment?

Gümüş¹,

Buduneli²

2014

BSBD

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Periodontitisin etkeni subgingival alanda yerleşip çoğalan patojen mikroorganizmalardır. Patojen bakteriler, diş yüzeylerine tutunur ve biofilm adı verilen karmaşık yapı içinde kolonize olur. Biyofilm, bakteriler için antimikrobiyal maddelere karşı korunaklı bir ortam sağladığından mekanik olarak diş yüzeyi temizliği ve kök yüzeyi düzleştirilmesi işlemleri yapılmaksızın tek başına uygulanan antibiyotikler ile periodontal tedavi sağlanamaz. Periodontal tedavide asıl hedef patojen bakterilerin diş yüzeylerinde yerleşmesini ve çoğalmasını önlemektir. Hastanın periodontal hastalıklar hakkında bilgilendirilmesi, iyi ağız bakımının öğretilmesi, diş yüzeyi temizliği ve kök yüzeyi düzleştirilmesi işlemlerini kapsayan cerrahisiz periodontal tedavi genellikle başarılı tedaviyi sağlar. Ancak, bazı durumlarda tedavinin etkinliğini arttırmak için tüm bu mekanik işlemlere ek olarak antibiyotiklerden de yararlanılır. Derleme türündeki bu makalede, hangi antibiyotikler, ne zaman, ne amaçla, nasıl periodontal tedavide mekanik işlemlere ek olarak kullanılmalı konularında güncel bilgilerin ortaya konulması amaçlanmıştır.

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Resistance of bacterial biofilms to disinfectants: a review

Cited by 741 publications

References 192 publications

Bacterial swimmers that infiltrate and take over the biofilm matrix

Bacterial swimmers that infiltrate and take over the biofilm matrix

Effect of Chlorhexidine and Sodium Hypochlorite on Staphylococcus aureus Biofilm

When and How to use Antibiotics in Periodontal Treatment?

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