Resistance of Candida albicans to antifungal drugs in Abidjan (Cote dIvoire)

Kouadio-Yapo, C. G.; Aka, N. A. D.; Bonouman-Ira, A. V.; Dou, Guiming; Sonan, K. H. G.; Zika, K. D.; Adoubryn, Koffi Daho; Dosso, M

doi:10.5897/ajmr2018.8817

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…In this study, we analysed 227 clinical yeast isolates, sampled from various sites, including vaginal swabs (120), pus (17), nails (14), semen (11), stool (7), skin flakes (5), urine (5), pharyngeal swabs (5), gastric fluid (1), respiratory samples (1), ascites (1), alveolar liquid (1, and CSF samples (1). The origin of 38 samples could not be determined.…”

Section: Sample Collectionmentioning

confidence: 99%

Identification, Prevalence and Susceptibility Profile of Candida Isolates at the Pasteur Institute in Côte D'ivoire from 2017 to 2019

A.V.,

R.,

et al. 2023

African Journal of Biology and Medical Research

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This study was conducted in Côte d’Ivoire to determine the respective prevalence of Candida species and to study their susceptibility profile to antifungal agents to identify the emergence of resistance.This retrospective study was conducted from 2017 to 2019 at the Institute Pasteur of Côte d’Ivoire on patients with fungal disease. The yeasts isolated and identified in Côte d’Ivoire were subcultured on a chromogenic medium and identified with MALDI-TOF-MS. Sensitivity tests were performed using the CLSI method and evaluated by the M27. In total, 227 Candida spp. were isolated from 1941 patients. Most of the samples were vaginal swabs (120/228). Using the conventional method, C. albicans was prevalent (52.6%). There were mixtures of 2 to 4 species in 36.8% of the samples. Thus MALDI-TOF-MS identified in 315 isolates 13 distinct species, C. tropicalis was prevalent at 35.2%, and the species in both C. albicans and C. parapsilosis complexes were differentiated. This study highlights the hurdle of correct yeast identification in developing countries. The transition from conventional to modern MALDI-TOF based identification of these life-threatening opportunistic pathogens is mandatory and should be emphasised as a public health priority.

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Section: Sample Collectionmentioning

confidence: 99%

Identification, Prevalence and Susceptibility Profile of Candida Isolates at the Pasteur Institute in Côte D'ivoire from 2017 to 2019

A.V.,

R.,

et al. 2023

African Journal of Biology and Medical Research

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A Novel Biocompatible and Biodegradable Electrospun Nanofibers Containing M. Neglectum: Antifungal Properties and In Vitro Investigation

Zarafshani

Mojarab

Zangeneh

et al. 2022

IEEE Trans.on Nanobioscience

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First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso

et al. 2022

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Background Vulvovaginal candidiasis is an important cause of morbidity among women due to Candida species. In the last decades, resistance to azoles, first-line antifungals has increased. One molecular mechanism of azole resistance by Candida involves mutations in the ERG11 gene encoding lanosterol 14-α-demethylase, the target enzyme. This study was conducted to identify the clinical Candida species associated in vulvovaginal candidiasis; to determine the rate of antifungal resistance among Candida albicans isolates and to determine mutated ERG11 gene at Saint Camille Hospital in Ouagadougou, Burkina Faso. Methods Antifungals susceptibility were performed using Kirby–Bauer disk diffusion method. ERG11 gene was detected using conventional PCR in C. albicans isolates resistant to at least one azole. Results Out of 262 clinical strains isolated, C. albicans accounted for 59.90%, followed by Candida glabrata 27.86%, Candida famata 7.25%, Candida tropicalis 3.05% and Saccharomyces cerevisiae 1.91%. Resistance rate of fluconazole to C. albicans was 59.54%. ERG11 gene was found in 9.79% of 92 C. albicans strains resistant to azoles. Conclusions This detection of mutated ERG11 gene in C. albicans is the first in Burkina Faso and may be a cause of azole resistance in recurrent Candida vulvovaginitis.

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Resistance of Candida albicans to antifungal drugs in Abidjan (Cote dIvoire)

Cited by 5 publications

References 33 publications

Identification, Prevalence and Susceptibility Profile of Candida Isolates at the Pasteur Institute in Côte D'ivoire from 2017 to 2019

Identification, Prevalence and Susceptibility Profile of Candida Isolates at the Pasteur Institute in Côte D'ivoire from 2017 to 2019

A Novel Biocompatible and Biodegradable Electrospun Nanofibers Containing M. Neglectum: Antifungal Properties and In Vitro Investigation

First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso

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