Resistance of Cardiac Mitochondria to Ischemia and Reperfusion in an Isolated Working Rat Heart Model of Donation After Circulatory Death

Wyss, Rahel K.; Carmona, Natalia Méndez; Sanz, María-Nieves; Arnold, Marlène; Carrel, Thierry; Djafarzadeh, Siamak; Stahel, Hendrik T. Tevaearai; Longnus, Sarah L.

doi:10.1097/01.tp.0000525061.88256.a5

Cited by 1 publication

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“…Another important observation was that, in general, hearts demonstrate a relatively good tolerance to WI periods <27 minutes. 23,24 Finally, once the heart is grafted and beating, the graft faces the additional handicap of immune-mediated rejection. The debris and byproducts of a damaged cell are referred to as Damage Associated Molecular Patterns (DAMPs) and serve as the initial triggers for the sterile inflammatory response.…”

Section: Pathophysiology In Cdcd Heart Donationmentioning

confidence: 99%

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Heart Donation From Donors After Controlled Circulatory Death

et al. 2021

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The gold-standard therapy for advanced-stage heart failure is cardiac transplantation. Since the first heart transplant in 1967, the majority of hearts transplanted came from brain death donors. Nevertheless, in recent years, the option of donation after circulatory death (DCD) is gaining importance to increase donor pool. Currently, heart-transplant programs using controlled donation after circulatory death (cDCD) have been implemented in the United Kingdom, Belgium, Australia, United States of America, and, recently, in Spain. In this article, we performed a concise review of the literature in heart cDCD; we summarize the pathophysiology involved in ischemia and reperfusion injury during this process, the different techniques of heart retrieval in cDCD donors, and the strategies that can be used to minimize the damage during retrieval and until transplantation. Heart transplant using DCD hearts is in continuous improvement and must be implemented in experienced cardiac transplant centers.

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Section: Pathophysiology In Cdcd Heart Donationmentioning

confidence: 99%

“…Another important observation was that, in general, hearts demonstrate a relatively good tolerance to WI periods <27 minutes. 23,24…”

Section: Pathophysiology In Cdcd Heart Donationmentioning

confidence: 99%