Resistance of E2F4DN to p38MAPKphosphorylation attenuates DNA damage-induced neuronal death via Cited2
Aina María Llabrés-Mas,
Alberto Garrido-García,
Vanesa Cano-Daganzo
et al.
Abstract:E2F4, a transcription factor with a prominent role in cell homeostasis, can be phosphorylated by the stress kinase p38MAPK at the Thr248/Thr250 motif, while the Thr248Ala/Thr250Ala E2F4 mutant (E2F4DN) triggers multifactorial therapeutic effects in a murine model of Alzheimer's disease. We hypothesized that the mechanism of action of this therapy relays on the phosphorylation of the Thr248/Thr250 motif under stress conditions, which prevents the homeostatic function of E2F4, while exogenous E2F4DN expression c… Show more
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