Resistance of experientially-induced changes in murine plus-maze behaviour to altered retest conditions

Rodgers, R.J.; Johnson, Norbert; Carr, Joshua K.; Hodgson, T.P

doi:10.1016/s0166-4328(96)02248-6

Cited by 52 publications

(25 citation statements)

References 38 publications

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“…An arm entry was considered when the animal entered it with all four paws. The number of open arm entries, time spent in open arms, and percentage of open arm entries are usually used to characterize anxiolytic effects of drugs (Pellow and File 1986;Rodgers et al 1997). Total arm entries are considered an indicator of the locomotor activity of the animals (Rodgers and Cole 1993;Espejo 1997;Zarrindast et al 2001), although closed arm entries could be even a better measure (Zarrindast et al 2000).…”

Section: Drugsmentioning

confidence: 99%

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Bupropion effects on aggressiveness and anxiety in OF1 male mice

et al. 2004

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During agonistic encounters the two sub-groups of mice (SL and LL) may display differential sensitivity in drug-induced changes on aggressiveness, since bupropion increased attack only in mice with "long attack latency" in the pre-screening test. In the plus-maze, this drug does not seem to have specific actions on anxiety and in the hole-board a high dose had similar effects to those induced by anxiogenic drugs.

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Section: Drugsmentioning

confidence: 99%

“…In Table 2, data are expressed as totals (total SAP and HD) and percent protected (% pSAP and % pHD). A decrease in total SAP and in the percentage of protected SAP and HD has usually been interpreted as anxiolytic (Rodgers et al 1997). …”

Section: Drugsmentioning

confidence: 99%

Bupropion effects on aggressiveness and anxiety in OF1 male mice

et al. 2004

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“…Par contre, le diazépam a entraîné une augmentation du nombre d'entrées et du temps passé dans les bras ouverts [F (3,53) = 3,78, P<0,05, Figure 3]. Considéré comme un des tests spécifiques pour l'étude de l'anxiété (Cruz et al, 1994;Hogg, 1996), ce dernier est aussi validé pour être utilisé avec la souris, et il a été prouvé que ce test est sensible pour les produits qui agissent par l'intermédiaire du récepteur GABA-A (Hogg, 1996;Rodgers et al, 1997). Raisons pour lesquelles, nous l'avons choisi pour étudier le potentiel anxiolytique de la 4-phényl-1,5-benzodiazépin-2-one.…”

Section: Discussionunclassified

Évaluation de l’activité anxiolytique de la 4-phenyl-1,5-benzodiazepin-2-one

Kanyonga¹,

Faouzi²,

Zellou³

et al. 2009

International Journal of Biological and Chemical Sciences

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RESUMELes effets pharmacologiques de la 4-phenyl-1,5-benzodiazepin-2-one ont été examinés chez des souris par des tests comportementaux classiques (Test de planche à trous, Test de labyrinthe et Test de la tige tournante) et comparés par rapport aux produits dont le potentiel anxiogenique ou anxiolytique sont connus. L'analyse de nos résultats a montré que la 4-phenyl-1,5-benzodiazepin-2-one et le diazépam ont augmenté le temps passé dans les bras ouverts, tandis que la picrotoxin a entraîné la diminution de ce temps. Considérant les résultats de l'évaluation de l'activité locomotrice, du comportement exploratoire et du comportement des animaux sur la tige tournante, le diazépam et la 4-phenyl-1,5-benzodiazepin-2-one ont influencé de façon significative ces derniers par rapport à la picrotoxin et au véhicule. Ces données suggèrent que la 4-phenyl-1,5-benzodiazepin-2-one possède une activité anxiolytique.

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“…search laboratories in the past 6 years (14-16) and has been extensively validated for use with both rats (2,15) and mice (1,11,13,17). The conventional indices of anxiety in this test, percent of open arm entries and percent time spent in the open arm, are exquisitely sensitive to agents thought to act via the GABA A receptor complex (i.e., benzodiazepines, barbiturates, ethanol, and neurosteroids) (14,17).…”

mentioning

confidence: 99%

“…The conventional indices of anxiety in this test, percent of open arm entries and percent time spent in the open arm, are exquisitely sensitive to agents thought to act via the GABA A receptor complex (i.e., benzodiazepines, barbiturates, ethanol, and neurosteroids) (14,17). For this reason, we chose this paradigm to investigate the anxiolytic potential of PTMB.…”

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confidence: 99%

Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice

Rubin

Albach

Berlese

et al. 2000

Braz J Med Biol Res

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The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic benzodiazepine, were examined in mice. In the elevated plus-maze test of anxiety, 0.3-1 mg/kg diazepam ip (F(3,53) = 3.78; P<0.05) and 1-10 mg/kg PTMB ip increased (F(5,98) = 3.26; P<0.01), whereas 2 mg/kg picrotoxin ip decreased (F(3,59) = 8.32; P<0.001) the proportion of time spent in the open arms, consistent with an anxiolytic action of both benzodiazepines, and an anxiogenic role for picrotoxin. In the holeboard, 1.0 mg/kg diazepam ip increased (F(3,54) = 2.78; P<0.05) and 2 mg/kg picrotoxin ip decreased (F(3,59) = 4.69; P<0.01) locomotor activity. Rotarod assessment revealed that 1 mg/kg diazepam ip and 3, 10 and 30 mg/kg PTMB ip produced significant motor incoordination compared to vehicle control (F(4,70) = 7.6; P<0.001). These data suggest that the recently synthesized PTMB compound possesses anxiolytic activity and produces motor incoordination similar to those observed with diazepam. PicrotoxinBenzodiazepine compounds have been reported to be the most extensively consumed psychoactive drugs worldwide due to their anxiolytic and anticonvulsant activity. However, undesirable side effects like muscle relaxation, sedation, physical dependence, tolerance, ataxia and memory impairment have been associated with the use of benzodiazepines. A variety of novel agents capable of interacting with benzodiazepine receptors have been investigated in order to develop non-sedative anxioselective agents (1-3). Two main hypotheses for the development of such anxioselective drugs have been proposed. The first suggests that different benzodiazepine receptor subtypes may be responsible for the behavioral effects of benzodiazepine compounds. According to this hypothesis, two receptor subtypes, benzodiazepine (omega) 1 and benzodiazepine (omega) 2 receptors, exist in different brain areas responsible for different physiological functions (2). The alternative hypothesis proposes the development of benzodiazepine receptor partial agonists which present lower intrinsic efficacy sufficient to maintain the anxiolytic and anticonvulsant responses, but insufficient to induce the side effects seen with full agonists (2,4). Most of the benzodiazepines used in clinical therapeutics are 1,4-benzodiazepines (5-7), since several products were generated by introducing substituents at different positions of the benzodiazepine ring of diazepam. Modifications in the structure of the ring have also been made, and the anxiolytic effect of 1,5-benzodiazepines (clobazam) has been described (8,9). However, considerably less is known about the effects of substituents on 1,5-benzodiazepines compared to the 1,4 group. In the present study we investigated the anxiolytic potential of the recently synthesized 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB) (10). The effects of this new benzodiazepine on spontaneous coordinated motor movements were also evaluated.Male albino mice (35-40 g) from our ...

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Resistance of experientially-induced changes in murine plus-maze behaviour to altered retest conditions

Cited by 52 publications

References 38 publications

Bupropion effects on aggressiveness and anxiety in OF1 male mice

Bupropion effects on aggressiveness and anxiety in OF1 male mice

Évaluation de l’activité anxiolytique de la 4-phenyl-1,5-benzodiazepin-2-one

Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice

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