Resistance of human syncytiotrophoblast to hypotonic and thermal stress

Abstract

Summary. Human placental syncytiotrophoblast was not lysed when exposed to acutely hypotonic environments (distilled water) or during repeated freeze\p=n-\thawing. The ability of the syncytiotrophoblast to synthesize and secrete hCG was not blocked after exposure to hypotonic stress (0\m=.\055osmol) and elevated temperature (47\s=deg\C),treatments which caused lysis of erythrocytes and lymphocytes. The stressresistant property of the syncytiotrophoblast may be an important element in enabling its survival as a barrier between the maternal environment and the conceptus.

Developmental Origins of Disease

“…In the past few years, a new field of research has developed that uses these organoids, enabling insights into human health and disease. These trophoblastorganoidscan survive long-term due to their characteristic properties [25,26], are genetically stable, and organize into villous-like structures that secrete essential proteins and hormones that would affect the mother's metabolism during the pregnancy. The Mini-placentas' could provide a model for early pregnancy.…”

Giant Cell: Cells Unite to Fight

“…It helps in selective bidirectional transport of material between the maternal and fetal circulation and also synthesizes protein and steroid hormones. 4 Apart from this the occurrence of polykaryons elsewhere is considered to be pathologic.The pathologic giant cells are Langhans' giant cells, foreign body giant cells, inflammatory giant cells, tumor giant cells and Touton giant cells. There are also miscellaneous types of giant cells such as Aschoff cells of rheumatic nodule and Reed Sternberg cells of Hodgkin's lymphoma.…”

Aspectos generales del transporte de colesterol en la esteroidogénesis de la placenta humana

“…Por ejemplo, luego de la incubación en un medio hipotónico o a temperaturas superiores a los 45°C, los explantes realizan todas sus funciones metabólicas, incluyendo la síntesis de progesterona, de manera similar a los explantes que no fueron expuestos a estos tratamientos. Los resultados muestran que la placenta humana contiene mecanismos de autopreservación y como estrategia fisiológica, un control metabólico y funcional independiente a los estímulos externos que desarrolló como una forma para proteger al producto (Paul, Jailkhani &Talwar, 1978, Paul, Gupta, Jailkhani &Talwar, 1980. En este sentido, se ha reportado que las mitocondrias de la placenta se adaptan de acuerdo con el avance del embarazo (Holland et al, 2017b).…”