2011
DOI: 10.1099/jmm.0.025619-0
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Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity

Abstract: Cationic antimicrobial agents may prevent device-associated infections caused by Staphylococcus epidermidis and Staphylococcus aureus. This study reports that the cationic antimicrobial polymer poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) was more effective at antagonizing growth of clinical isolates of S. epidermidis than of S. aureus. Importantly, mature S. epidermidis biofilms were significantly inactivated by pDMAEMA. The S. aureus isolates tested were generally more hydrophobic than the S. epidermi… Show more

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Cited by 48 publications
(47 citation statements)
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“…The only significant differences are the surface hydrophobicity and charge values. It was previously confirmed, using multiple strains, that S. aureus is more hydrophobic than S. epidermidis , and that it has a smaller negative charge [32,33,34,35]. Moreover, the carotenoid pigments of S. aureus and antioxidant enzymes, particularly catalase, promote more powerful oxidant resistance.…”
Section: Resultsmentioning
confidence: 99%
“…The only significant differences are the surface hydrophobicity and charge values. It was previously confirmed, using multiple strains, that S. aureus is more hydrophobic than S. epidermidis , and that it has a smaller negative charge [32,33,34,35]. Moreover, the carotenoid pigments of S. aureus and antioxidant enzymes, particularly catalase, promote more powerful oxidant resistance.…”
Section: Resultsmentioning
confidence: 99%
“…For antimicrobial chemotherapy using the antimicrobial polymers and their assemblies, a scrutinity of cytotoxic effects on different cell types and on in vivo animal models will be required before biomedical applications can be achieved. Furthermore, there are reports on development of resistance against cationic antimicrobial polymers [283]. The cationic antimicrobial polymer poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) was more effective at antagonizing growth of clinical isolates of Staphylococcus epidermidis than of S. aureus and this was due to the fact that the S. aureus isolates tested were generally more hydrophobic than the S. epidermidis isolates and had a less negative charge [283].…”
Section: The Antimicrobial Supramolecular Assembliesmentioning
confidence: 99%
“…Furthermore, there are reports on development of resistance against cationic antimicrobial polymers [283]. The cationic antimicrobial polymer poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) was more effective at antagonizing growth of clinical isolates of Staphylococcus epidermidis than of S. aureus and this was due to the fact that the S. aureus isolates tested were generally more hydrophobic than the S. epidermidis isolates and had a less negative charge [283]. A high content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures revealed several toxicological aspects of the cationic polymer [284].…”
Section: The Antimicrobial Supramolecular Assembliesmentioning
confidence: 99%
“…One could thus reasonably speculate that in the presence of a sufficiently anionic bacterial surface, peptide-bacteria interaction would be favoured even in the presence of serum. According to published reports, S. epidermidis has a more anionic surface than S. aureus [77,78], which might explain the generally higher activity observed for the three short AMPs against S. epidermidis strains as compared to S. aureus (Tables 2 and 3). Moreover, for the same reason, S. epidermidis could be less prone to shielding by serum, and this is particularly evident for the less hydrophobic and more cationic B27 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”
Section: Discussionmentioning
confidence: 87%